Surgical History and the Risk of Endometriosis:A Hospital-Based Case-Control Study

Xishi Liu, Qiqi Long, Sun-Wei Guo, Sun‐Wei Guo
Reproductive sciences (Thousand Oaks, Calif.) · 2016 · vol. 23(9) , pp. 1217–1224 · doi:10.1177/1933719116632921 · PMID:26919976 · W2414628583
article OA: closed CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This hospital-based case-control study found that laparotomy and cesarean sections were associated with an increased risk of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This hospital-based case-control study evaluated whether surgical history after menarche is associated with endometriosis by comparing 208 patients with ovarian endometrioma to 212 age-matched patients with ovarian teratoma, using detailed self-reported records of prior procedures categorized by laparotomy, laparoscopy, cesarean section, and other sites. Cases and controls were similar in age and several socioeconomic variables, and multivariate analysis found age at index surgery, prior laparotomy, and cesarean section were positively associated with endometriosis risk, with laparotomy showing an OR of 3.64 and cesarean section an OR of 2.16. The paper notes biological rationale via activation of adrenergic signaling that could facilitate angiogenesis and growth of existing lesions, but the primary limitation is its retrospective, hospital-based design and reliance on surgical history documentation after menarche. This paper is centrally about endometriosis — it tests whether prior surgical procedures (especially laparotomy and cesarean section) increase the risk of ovarian endometrioma.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Postoperative Complications Adult Case-Control Studies Cesarean Section Cesarean Section Endometriosis Endometriosis Female Hospitals Humans Laparoscopy Laparoscopy Laparotomy Laparotomy Menarche Middle Aged Multivariate Analysis Risk Factors

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