Evaluation of stress-related hormones after surgery by laparoscopy or laparotomy

L Muzii, Ludovico Muzii, Riccardo Marana, Marana R, R Marana, E Marana, Marana E, Elisabetta Marana, Paielli FV, F V Paielli, FRANCESCO V. PAIELLI, Francesco Di Meo, F Meo, Meo F, M L Maussier, Maussier ML, Ml Maussier, Mario Sciarra, M Sciarra, Sciarra M, Salvatore Mancuso, S Mancuso, Mancuso S
The Journal of the American Association of Gynecologic Laparoscopists · 1996 · vol. 3(2) , pp. 229–234 · doi:10.1016/s1074-3804(96)80005-3 · PMID:9050631 · W1980709092
article OA: closed CC0 ⤵ 4 in-corpus citations
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This study compared stress hormone levels in patients undergoing surgery via laparoscopy versus laparotomy to evaluate the impact of surgical approach on physiological stress response.

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Abstract

Study objectiveTo evaluate the stress hormone response after pelvic surgery performed by laparoscopy versus laparotomy.DesignProspective study.SettingA tertiary care university hospital.PatientsTen women were scheduled to undergo laparoscopic surgery and 10 laparotomy for either tubal disease or endometriosis.InterventionsSurgical procedures were performed by laparoscopy or laparotomy for stage III-IV endometriosis, pelvic adhesions, or distal tubal occlusion. The following hormones were measured before the induction of anesthesia in the ward, 60 minutes after the beginning of surgery, at the end of surgery after extubation, and 2 hours and 6 hours after the end of the operation: norepinephrine (NE), epinephrine (E), dopamine (D), adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), and GH.Measurements and main resultsThe mean duration of surgery was not significantly different between the two groups. Surgery-related adrenergic activation (E, NE, D) appears more pronounced in the laparotomy group (p<0.005) during surgery and in the postoperative period. More elevated values for laparotomy were observed also for the other stress hormones (ACTH, cortisol, PRL, GH), even though statistical significance was not always reached.ConclusionsCompared with laparotomy, activation of stress-related factors during laparoscopy seems to be less intense and of shorter duration.

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Condition tags

endometriosis

MeSH descriptors

Adrenocorticotropic Hormone Biogenic Monoamines Endometriosis Fallopian Tube Diseases Laparoscopy Laparotomy Stress, Physiological Adrenocorticotropic Hormone Adult Biogenic Monoamines Endometriosis Endometriosis Epinephrine Epinephrine Fallopian Tube Diseases Fallopian Tube Diseases Female Growth Hormone Growth Hormone Humans

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