Luteinizing hormone beta-subunit gene (LHbeta) polymorphism in infertility and endometriosis-associated infertility

Fernanda A Mafra, Mafra FA, Fernanda Mafra, Bianca Bianco, Denise M Christofolini, Denise Maria Christofolini, Ângela Mara Bentes de Souza, Angela M B Souza, Souza AM, Karina Zulli, Zulli K, Caio Parente Barbosa, Caio P Barbosa
European journal of obstetrics, gynecology, and reproductive biology · 2010 · vol. 151(1) , pp. 66–69 · doi:10.1016/j.ejogrb.2010.03.022 · PMID:20430510 · W2156031979
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This paper investigated the luteinizing hormone β-subunit gene (LHβ) polymorphism's association with infertility and endometriosis-associated infertility.

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Abstract

OBJECTIVE: To establish the frequency of LHbeta G1502A polymorphism in infertile women with endometriosis, infertile women without endometriosis and a control group. STUDY DESIGN: Case-control study including 110 infertile women with endometriosis, 84 infertile women without endometriosis and a control group consisting 209 healthy fertile women recruited from the ABC School of Medicine. The LHbeta G1502A polymorphism was studied by RPLP-PCR (restriction fragment length polymorphism-polymerase chain reaction). RESULTS: Genotypes GG, GA and AA of the LHbeta G1502A polymorphism presented frequencies of 54.6%, 31.8% and 13.6%, respectively, in the women with endometriosis (p=0.0398); of 52.4%, 38.1% and 9.5% (p=0.0123), respectively, in the infertile women without endometriosis; and of 68.9%, 21.5% and 9.6%, respectively, in the control group. In patients with minimal/mild endometriosis and moderate/severe endometriosis, the GG, GA and AA genotype frequencies were, respectively, 47.3%, 36.4% and 16.3% (p=0.0118); and 61.8%, 27.3% and 10.9% (p=0.5975). Considering the alleles, allele G was present in 70.5% of the patients with endometriosis, 71.4%% of the infertile women without endometriosis and in 79.7% of the controls, whereas allele A was present in 29.5%, 28.6% and 20.3%, respectively, in the infertile women with endometriosis (p=0.0121), infertile women without endometriosis (p=0.0409) and controls. Alleles G and A presented frequencies of 65.5% and 34.5% and 75.5% and 24.5%, respectively, in minimal/mild endometriosis (p=0.0026) and moderate/severe endometriosis (p=0.4062). CONCLUSION: The data suggest that LHbeta G1502A polymorphism may be involved in the predisposition to infertility and minimal/mild endometriosis-associated infertility, although endometriosis might be only a coincidental finding along with infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Luteinizing Hormone, beta Subunit Adult Adult Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Humans Humans Infertility, Female Infertility, Female Luteinizing Hormone, beta Subunit Luteinizing Hormone, beta Subunit Polymorphism, Genetic Polymorphism, Genetic

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