Fibrogenesis in peritoneal endometriosis. A semi-quantitative analysis of type-I collagen
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This study found that black peritoneal endometriosis lesions contain significantly more type-I collagen in their stroma compared to red lesions, indicating greater fibrosis.
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Abstract
OBJECTIVE: To evaluate the degree of fibrosis in the stroma of peritoneal endometriosis, according to the macroscopic appearance.
METHODS: Red and black lesions of peritoneal endometriosis were collected and type-I collagen was immunohistochemically identified. The percentage of the stained area in the stroma was measured using a computerized image analysis system.
RESULTS: There was a significant difference in the mean percentage of the total stained area between red and black lesions.
CONCLUSION: The amount of type-I collagen is significantly higher in the stroma of black peritoneal lesions than in red peritoneal lesions.
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Cited by (47)
- Integrated single-cell and spatial transcriptomics reveal divergent immunological and stromal programs in peritoneal versus ovarian endometriosis 2026
- In vitro Effects of ABT-263, a BH3 Mimetic, on Fibrotic Phenotype in Endometriotic and Endometrial Stromal Cells 2025
- Advancements in Ultrasound Diagnosis of Superficial Endometriosis: Current Challenges and Emerging Techniques 2025
- The role of fibrosis in endometriosis: a systematic review 2024
- Impacts of endometrioma on ovarian aging from basic science to clinical management 2023
- Neferine mediated TGF-β/ERK signaling to inhibit fibrosis in endometriosis 2023
- IL-10 is not anti-fibrotic but pro-fibrotic in endometriosis: IL-10 treatment of endometriotic stromal cells in vitro promotes myofibroblast proliferation and collagen type I protein expression 2022
- Persistent activation of signal transducer and activator of transcription 3 via interleukin-6 trans-signaling is involved in fibrosis of endometriosis 2022
- The roles and functions of macrophages in endometriosis 2021
- Comparison of pain intensity, smooth muscle cells density, and alpha-smooth muscle actin expression in ovarial and peritoneal endometriosis 2021
- Dose-dependent pro- or anti-fibrotic responses of endometriotic stromal cells to interleukin-1β and tumor necrosis factor α 2020
- The quest for genetic sequence variants conferring risk of endometriosis 2020
- Relaxin-2 May Suppress Endometriosis by Reducing Fibrosis, Scar Formation, and Inflammation 2020
- Hyperactivation of dormant primordial follicles in ovarian endometrioma patients 2020
- Loss of HDAC3 results in nonreceptive endometrium and female infertility 2019
- Endometriotic Peritoneal Fluid Promotes Myofibroblast Differentiation of Endometrial Mesenchymal Stem Cells 2019
- Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review 2019
- Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium 2018
- Pathogenesis of endometriosis: Interaction between Endocrine and inflammatory pathways 2018
- Effects of matrix stiffness on epithelial to mesenchymal transition-like processes of endometrial epithelial cells: Implications for the pathogenesis of endometriosis 2017
- Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis 2017
- Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response 2017
- Soft matrices inhibit cell proliferation and inactivate the fibrotic phenotype of deep endometriotic stromal cells in vitro 2016
- Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation 2016
- P-selectin as a potential therapeutic target for endometriosis 2015
- Co-operation between the AKT and ERK signaling pathways may support growth of deep endometriosis in a fibrotic microenvironment in vitro 2015
- Targeting the Wnt/β-catenin pathway in endometriosis: a potentially effective approach for treatment and prevention 2014
- Potential New Drugs for Endometriosis: Experimental Evidence 2014
- Antifibrotic properties of epigallocatechin-3-gallate in endometriosis 2014
- Possible Loss of GABAergic Inhibition in Mice With Induced Adenomyosis and Treatment With Epigallocatechin-3-Gallate Attenuates the Loss With Improved Hyperalgesia 2014
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- RHOC: a key gene for endometriosis 2013
- Involvement of the Wnt/β-catenin signaling pathway in the cellular and molecular mechanisms of fibrosis in endometriosis 2013
- Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis 2011
- Mevalonate-Ras Homology (Rho)/Rho-Associated Coiled-Coil-Forming Protein Kinase (ROCK)-Mediated Signaling Pathway as a Therapeutic Target for the Treatment of Endometriosis-Associated Fibrosis 2010
- Heparin is a promising agent for the treatment of endometriosis-associated fibrosis 2009
- Decidualization attenuates the contractility of eutopic and ectopic endometrial stromal cells: implications for hormone therapy of endometriosis 2009
- Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis 2009
- Endometriosis 2009
- Endometrial-peritoneal interactions during endometriotic lesion establishment 2008
- Collagen gel contractility is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis-associated fibrosis 2007
- Endométriose et douleur 2007
- Endometriosis and pain 2007
- Vascular development in endometriosis 2005
- Expression of the cyclin-dependent kinase inhibitor p27Kip1 in eutopic endometrium and peritoneal endometriosis 2001
- Adhesion prevention in the surgical treatment of pelvic endometriosis 2001
- Smooth muscles are frequent components of endometriotic lesions 2000
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