Treatment

In: Deep Pelvic Endometriosis · 2011 · pp. 47–78 · doi:10.1007/978-88-470-1866-2_3 · W4210995845
book-chapter OA: closed CC0
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06+body, 2026-06-23

Surgical resection is the primary treatment for symptomatic deeply infiltrating endometriosis, aiming for complete lesion removal, often requiring multidisciplinary teams and yielding similar results via laparoscopy or laparotomy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-23 · read from full text

This paper discusses treatment strategies for deeply infiltrating endometriosis, focusing on endocrine pharmacotherapy as neo-adjuvant or adjuvant therapy and, in most symptomatic cases, surgical resection as the treatment of choice, with the aim of removing all endometriotic lesions in a single operation. It summarizes retrospective evidence for pain improvements after conservative surgery, while noting that long-term follow-up data are limited, and it outlines procedures matched to organ involvement (e.g., bowel resections for rectal/rectosigmoid disease, transurethral or partial cystectomy for bladder involvement, and ureterolysis/ureteral reconstruction for ureter involvement). It reports that laparoscopic and laparotomic resections achieve similar symptom control, though disease complexity and extensive extragenital involvement may necessitate laparotomy and can raise conversion risk. Relevance to endometriosis: the paper is centrally about the treatment of deeply infiltrating endometriosis, including surgical approaches for rectal, bladder, and ureter involvement, and it also references limited long-term follow-up across surgical studies, though it does not address adenomyosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 22,360 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

Endocrine pharmacotherapy can be used as a neo-adjuvant or adjuvant measure; however, in the majority of symptomatic cases, surgical resection is the treatment of choice for deeply infiltrating endometriosis, to improve pain, quality of life, and possibly fertility. The goal should be to achieve the complete treatment of all endometriotic lesions by a single operation. Since more complex cases require resection of the intestinal wall and/or bladder or ureter, the expertise and cooperation of different specialists, namely colorectal and urologic surgeons, is warranted. Many retrospective studies have demonstrated the beneficial effect of conservative surgery for pain symptoms; however, few studies have reported long-term follow-up data In the case of rectal or rectosigmoid involvement, a formal bowel resection, rather than partial excision, is most often preferable, despite the fact that it entails a higher risk of intraoperative and postoperative complications. In cases of bladder endometriosis, transurethral resection, partial cystectomy, or combined operations can be performed, whereas, when the ureter is involved, ureterolysis, ureterostomy, and ureteral reimplantation are carried out. Laparoscopic and laparotomic resections achieve the same results in terms of symptom control, although the complexity of the disease or extensive involvement of extragenital organs sometimes requires laparotomy, or carries a high risk of conversion. Data on reoperation for rectovaginal endometriosis and repetitive conservative surgery are scant. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

Mechsner S, Bartley J, Loddenkemper C et al. Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts. Fertil Steril 2005;83(S1):1220–1231 Bulun SE. Endometriosis. N Engl J Med 2009;360:268–279 Ferrero S, Gillott DJ, Remorgida V et al. Proteomics technologies in endometriosis. Expert Rev Proteomics 2008;5:705–714 Ebert AD, Jakisch D, Müller MD et al. Endometriosezentren verschiedener Stufen zur Verbesserung der medizinischen Versorgungsqualität, der Forschung sowie der ärztlichen Fort-und Weiterbildung. J Gynäkol Endokrinol 2008; 18:62–68 Garry R. The effectiveness of laparoscopic excision of endometriosis. Curr Opin Obstet Gynecol 2004; 16:299–303 Davis CJ, McMillan L. Pain in endometriosis: effectiveness of medical and surgical management. Curr Opin Obstet Gynecol 2003; 15:507–512 Jacobson TZ, Barlow DH, Garry R, Koninckx P. Laparoscopic surgery for pelvic pain associated with endometriosis. Cochrane Database Syst Rev 2009;4:CD001300 Fedele L, Bianchi S, Zanconato G et al. Is rectovaginal endometriosis a progressive disease? Am J Obstet Gynecol 2004;191:1539–1542 Chapron C, Dubuisson JB, Chopin N et al. Deeply infiltrating endometriosis: management and proposal for a “surgical classification”. Gynecol Obstet Fertil 2003;31:197–206 De Nardi P, Osman N, Ferrari S et al. Laparoscopic treatment of deep pelvic endometriosis with rectal involvement. Dis Colon Rectum 2009;52:419–424 Chapron C, Dubuisson J-B. Management of deep endometriosis. Ann NY Acad Sci 2001;943:276–280 Chapron C, Fauconnier A, Vieira M et al. Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification. Hum Reprod 2003; 18:157–161 Brouwer R, Woods RJ. Rectal endometriosis: results of radical excision and review of published work. ANZ J Surg 2007;77:562–571 Jerby BL, Kessler H, Falcone T, Milsom JW. Laparoscopic management of colorectal endometriosis. Surg Endosc 1999;13:1125–1128 Davis CJ, McMillan L. Pain in endometriosis: effectiveness of medical and surgical Management. Curr Opin Obstet Gynecol 2003;15:507–512 Doyle JB. Paracervical uterine denervation by transection of the cervical plexus for the relief of dysmenorrhea. Am J Obstet Gynecol 1955;70:1–16 Proctor ML, Latthe PM, Farquhar CM et al. Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev 2005;(4):CD001896 Johnson NP, Farquhar CM, Crossley S et al. A double-blind randomised controlled trial of laparoscopic uterine nerve ablation for women with chronic pelvic pain. Int J Obstet Gynecol 2004;111:950–959 Sutton C, Pooley AS, Jones KD et al. A prospective, randomised, double blind controlled trial of laparoscopic uterine nerve ablation in the treatment of pelvic pain associated with endometriosis. Gynecol Endosc 2001;10:217–222 Lichten EM, Bormbard J. Surgical treatment of primary dysmenorrhea with laparoscopic uterine nerve ablation. J Reprod Med 1987;32:37–41 Candiani GB, Fedele L, Vercellini P et al. Presacral neurectomy for the treatment of pelvic pain associated with endometriosis: a controlled study. Am J Obstet Gynecol 1992; 167:100–103 Kwok A, Lam A, Ford R. Laparoscopic presacral neurectomy: a review. Obstet Gynecol Surv 2001;56:99–104 Soysal ME, Soysal S, Gurses E, Ozer S. Laparoscopic presacral neurolysis for endometriosis-related pelvic pain. Hum Reprod 2003;18:588–592 Redwine DB, Wright JT. Laparoscopic treatment of complete obliteration of the cul-de-sac associated with endometriosis: long-term follow-up of en bloc resection. Fertil Steril 2001;76:358–365 Abrão MS, Neme RM, Averbach M. Endometriose de septo reto-vaginal: doença de diagnóstico e tratamento específicos. Arq Gastroenterol 2003;40:192–197 Angioni S, Peiretti M, Zirone M et al. Laparoscopic excision of posterior vaginal fornix in the treatment of patients with deep endometriosis without rectum involvement: surgical treatment and long-term follow-up. Hum Reprod 2006;21:1629–1634 Chapron C, Jacob S, Dubuisson J-B et al. Laparoscopically assisted vaginal management of deep endometriosis infiltrating the rectovaginal septum. Acta Obstet Gynecol Scand 2001;80:349–354 Fedele L, Bianchi S, Zanconato G et al. Long-term follow-up after conservative surgery for rectovaginal endometriosis. Am J Obstet Gynecol 2004; 190:1020–1024 Campagnacci R, Perretta S, Guerrieri M et al. Laparoscopic colorectal resection for endometriosis. Surg Endosc 2005;19:662–664 Bailey HR, Ott MT, Hartendorp P. Aggressive surgical management for advanced colorectal endometriosis. Dis Colon Rectum 1994;37:747–752 Urbach DR, Reedijk M, Richard CS et al. Bowel resection for intestinal endometriosis. Dis Colon Rectum 1998;41:1158–1164 Mourthé de Alvim Andrade M, Batista Pimenta M, de Freitas Belezia B, Duarte T. Rectal obstruction due to endometriosis. Tech Coloproctol 2008; 12:57–59 Thomassin I, Bazot M, Detchev R et al. Symptoms before and after surgical removal of colorectal endometriosis that are assessed by magnetic resonance imaging and rectal endoscopic sonography. Am J Obstet Gynecol 2004;190:1264–1271 Darai E, Thomassin I, Barranger E et al. Feasibility and clinical outcome of laparoscopic colorectal resection for endometriosis. Am J Obstet Gynecol 2005; 192:394–400 Remorgida V, Ferrero S, Fulcheri E et al. Bowel endometriosis: presentation, diagnosis, and treatment. Obstetric Gynecol Surv 2007;62:461–470 Healey M, Ang WC, Cheng C. Surgical treatment of endometriosis: a prospective randomized double-blinded trial comparing excision and ablation. Fertil Steril 2010;March 30 [epub ahead of print] Donnez J, Squifflet J. Complications, pregnancy and recurrence in a prospective series of 500 patients operated on by the shaving technique for deep rectovaginal endometriotic nodules. Human Reproduction, 2010;25(8): 1949–1958 Nezhat C, Nezhat F, Pennington E et al. Laparoscopic disk excision and primary repair of the anterior rectal wall for the treatment of full-thickness endometriosis. Surg Endosc 1994;8:682–685 Gordon SJ, Maher PJ, Woods R. Use of the CEEA stapler to avoid ultra-low segmental resection of a full-thickness rectal endometriotic nodule. J Am Assoc Gynecol Laparosc 2001;8:312–316 Woods RJ, Heriot AG, Chen FC. Anterior rectal wall excision for endometriosis using the circular stapler. ANZ J Surg 2003;73:647–648 Reich H. Laparoscopic hysterectomy for advanced endometriosis. In: Jain N (ed) Atlas of endoscopic surgery in infertility and gynecology. McGraw-Hill, New York (NY), 2004, pp 298–320 Remorgida V, Ragni N, Ferrero S et al. The involvement of the interstitial Cajal cells and the enteric nervous system in bowel endometriosis. Hum Reprod 2005;20:264–271 Remorgida V, Ragni N, Ferrero S et al. How complete is full thickness disc resection of bowel endometriotic lesions? A prospective surgical and histological study. Hum Reprod 2005;20:2317–2320 Anaf V, El Nakadi I, Simon P et al. Preferential infiltration of large bowel endometriosis along the nerves of the colon. Hum Reprod 2004; 19:996–1002 Abrão MS, Podgaec S, Dias JA Jr et al. Endometriosis lesions that compromise the rectum deeper than the inner muscularis layer have more than 40% of the circumference of the rectum affected by the disease. J Minim Invasive Gynecol 2008; 15:280–285 Kavallaris A, Koèhler C, Kuèhne-Heid R, Schneider A. Histopathological extent of rectal invasion by rectovaginal endometriosis. Hum Reprod 2003; 18:1323–1327 Roman H. Guidelines for the management of painful endometriosis. J Gynecol Obstet Biol Reprod 2007;33:141–150 Roman H, Opris I, Resch B et al. Histopathologic features of endometriotic rectal nodules and the implications for management by rectal nodule excision. Fertil Steril 2009;92:1250–1252 Busacca M, Somigliana E, Bianchi S et al. Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III–IV: a randomized controlled trial. Hum Reprod 2001;16:2399–2402 Nezhat F, Nezhat C, Pennington E. Laparoscopic proctectomy for infiltrating endometriosis of the rectum. Fertil Steril 1992;57:1129–1132 Redwine DB, Koning M, Sharpe DR. Laparoscopically assisted transvaginal segmental resection of the rectosigmoid colon for endometriosis. Fertil Steril 1996;65:193–197 Fleisch MC, Xafis D, De Bruyne F et al. Radical resection of invasive endometriosis with bowel or bladder involvement — long-term results. Eur J Obstet Gynecol Reprod Biol 2005; 123:224–229 Abbott A, Hawe J, Clayton RD, Garry R. The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2 ± 5 year follow-up. J Hum Reprod 2003;18:1922–1927 Darai E, Ackerman G, Bazot M et al. Laparoscopic segmental colorectal resection for endometriosis: limits and complications. Surg Endosc 2007;21:1572–1577 Seracchioli R, Poggioli G, Pierangeli F et al. Surgical outcome and long-term follow up after laparoscopic rectosigmoid resection in women with deep infiltrating endometriosis. BJOG 2007;114:889–895 Busacca M, Chiaffarino F, Candiani M et al. Determinants of long-term clinically detected recurrence rates of deep, ovarian, and pelvic endometriosis. Am J Obstet Gynecol 2006;195:426–432 Redwine DB, Sharpe DR. Laparoscopic segmental resection of the sigmoid colon for endometriosis. J Laparoendosc Surg 1991;1:217–220 Duepree HJ, Senagore AJ, Delaney CP et al. Laparoscopic resection of deep pelvic endometriosis with rectosigmoid involvement. J Am Coll Surg 2002; 195:254–258 Marpeau O, Thomassin I, Barranger E et al. Résection coelioscopique du colon-rectum pour endométriose: résultats preliminaires. J Gynecol Obstet Biol Reprod 2004;33:600–606 Dubernard G, Piketty M, Rouzier R et al. Quality of life after laparoscopic colorectal resection for endometriosis. Hum Reprod 2006;21:1243–1247 Mereu L, Ruffo G, Landi S et al. Laparoscopic treatment of deep endometriosis with segmental colorectal resection: short-term morbidity. J Minim Invasive Gynecol 2007; 14:463–469 Ruffo G, Scopelliti F, Scioscia M et al. Laparoscopic colorectal resection for deep infiltrating endometriosis: analysis of 436 cases. Surg Endosc 2010;24:63–67 Fayez J, Collazo LM. Comparison between laparotomy and operative laparoscopy in the treatment of moderate and severe endometriosis. Int J Fertil 1990;35:272–279 Crosignani PG, Vercellini P, Biffignandi F et al. Laparoscopy versus laparotomy in conservative surgical treatment for severe endometriosis. Fertil Steril 1996;66:706–711 Darai E, Dubernard G, Coutant C et al. Randomized trial of laparoscopically assisted versus open colorectal resection for endometriosis morbidity, symptoms, quality of life, and fertility. Ann Surg 2010;251:1018–1023 Ford J, English J, Miles WA, Giannopoulos T. Pain, quality of life and complications following the radical resection of rectovaginal endometriosis. Int J Gynaecol Obstet 2004; 111:353–356 Benbara A, Fortin B, Martin L et al. Résection rectosigmoidienne pour endométriose profonde: resultats chirurgicaux et fonctionnels. [Surgical and functional results of colorectal resection for severe endometriosis.] Gynecol Obstet Fertil 2008;36:1191–1201 Golfier F, Sabra M. Surgical management of endometriosis. J Gynecol Obstet Biolog Reprod 2007;36:162–172 Roman H, Loise C, Resch B et al. Delayed functional outcomes associated with surgical management of deep rectovaginal endometriosis with rectal involvement: giving patients an informed choice. Hum Reprod 2010;25(4):890–899 Ret Dávalos ML, De Cicco C, D’Hoore A et al. Outcome after rectum or sigmoid resection: a review for gynecologists. J Min Inv Gynecol 2007; 14:33–38 Dubernard G, Rouzier R, David-Montefiore E et al. Urinary complications after surgery for posterior deep infiltrating endometriosis are related to the extent of dissection and to uterosacral ligaments resection. J Minim Invasive Gynecol 2008; 15:235–240 Comiter CV. Endometriosis of the urinary tract. Urol Clin North Am 2002;29:625–635 Donnez J, Van Langendonckt A, Casanas-Roux F et al. Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Invest 2002;54(S1):52–58 Fedele L, Bianchi S, Zanconato G et al. Long-term follow-up after conservative surgery for bladder endometriosis. Fertil Steril 2005;83:1729–1733 Garry R. Endometrial ablation and resection: validation of a new surgical concept. Br J Obstet Gynaecol 1997;104:1329–1331 Chopin N, Vieira M, Borghese B et al. Operative management of deeply infiltrating endometriosis: results on pelvic pain symptoms according to a surgical classification. J Minim Invasive Gynecol 2005;12:106–112 Vignali M, Bianchi S, Candiani M et al. Surgical treatment of deep endometriosis and risk of recurrence. J Minim Invasive Gynecol 2005;12:508–513 Antonelli A, Simeone C, Canossi E et al. Surgical approach to urinary endometriosis: experience on 28 cases. Arch Ital Urol Androl 2006;78:35–38 Gustilo-Ashby AM, Paraiso MF. Treatment of urinary tract endometriosis. J Minim Invasive Gynecol 2006; 13:559–565 Granese R, Candiani M, Perino A et al. Bladder endometriosis: laparoscopic treatment and follow-up. Eur J Obstet Gynecol Reprod Biol 2008; 140:114–117 Vercellini P, Meschia M, De Giorgi O et al. Bladder detrusor endometriosis: clinical and pathogenetic implications. J Urol 1996;155:84–86 Dubuisson JB, Chapron C. Classification of endometriosis. The need for modification. Hum Reprod 1994;9:2214–2216 Seracchioli R, Mabrouk M, Montanari G et al. Conservative laparoscopic management of urinary tract endometriosis (UTE): surgical outcome and long-term follow-up. Fertil Steril 2010;94:856–861 Chapron C, Dubuisson JB. Laparoscopic management of bladder endometriosis. Acta Obstet Gynecol Scand 1999;78:887–890 Nezhat C, Nezhat F, Nezhat CH et al. Urinary tract endometriosis treated by laparoscopy. Fertil Steril 1996;66:920–924 Nezhat CH, Malik S, Osias J et al. Laparoscopic management of 15 patients with infiltrating endometriosis of the bladder and a case of primary intravesical endometrioid adenosarcoma. Fertil Steril 2002;78:872–875 Chapron C, Dubuisson JB, Jacob S et al. Laparoscopy and bladder endometriosis. Gynecol Obstet Fertil 2000;28:232–237 Donnez J, Spada F, Squifflet J, Nisolle M. Bladder endometriosis must be considered as bladder adenomyosis. Fertil Steril 2000;74:1175–1181 Chapron C, Bourret A, Chopin N et al. Surgery for bladder endometriosis: long-term results and concomitant management of associated posterior deep lesions. Hum Reprod 2010;25:884–889 Pang ST, Chao A, Wang CJ et al. Transurethral partial cystectomy and laparoscopic reconstruction for the management of bladder endometriosis. Fertil Steril 2008;90:2014 Sener A, Chew BH, Duvdevani M et al. Combined transurethral and laparoscopic partial cystectomy and robot-assisted bladder repair for the treatment of bladder endometrioma. J Minim Invasive Gynecol 2006; 13:245–248 Pastor-Navarro H, Giménez-Bachs JM, Donate-Moreno MJ et al. Update on the diagnosis and treatment of bladder endometriosis. Int Urogynecol J Pelvic Floor Dysfunct 2007; 18:949–954 Collinet P, Marcelli F, Villers A et al. Management of endometriosis of the urinary tract. Gynecol Obstet Fertil 2006;34:347–352 Douglas C, Rotimi O. Extragenital endometriosis — a clinicopathological review of a Glasgow hospital experience with case illustrations. J Obstet Gynaecol 2004;24:804–808 Yohannes P. Ureteral endometriosis. J Urol 2003; 170:20–25 Kinkel K, Frei KA, Balleyguier C, Chapron C. Diagnosis of endometriosis with imaging: a review. Eur Radiol 2006; 16:285–298 Frenna V, Santos L, Ohana E et al. Laparoscopic management of ureteral endometriosis: our experience. J Minim Invasive Gynecol 2007; 14:169–171 Nezhat C, Silfen S, Nezhat F, Martin D. Surgery for endometriosis. Curr Opin Obstet Gynecol 1991;3:385–393 Chung H, Jeong BC, Kim HH. Laparoscopic ureteroneocystostomy with vesicopsoas hitch: nonrefluxing ureteral reimplantation using cystoscopy-assisted submucosal tunneling. J Endourol 2006;20:632–638 Ghezzi F, Cromi A, Bergamini V et al. Outcome of laparoscopic ureterolysis for ureteral endometriosis. Fertil Steril 2006;86:418–422 Mereu L, Gagliardi ML, Clarizia R et al. Laparoscopic management of ureteral endometriosis in case of moderate-severe hydroureteronephrosis. Fertil Steril 2010;93:46–51 Grainger DA, Soderstrom RM, Schiff SF et al. Ureteral injuries at laparoscopy: insights into diagnosis, management and prevention. Obstet Gynecol 1990;76:889–890 Rafique M, Arif MH. Management of iatrogenic ureteric injuries associated with gynaecological surgery. Int Urol Nephrol 2002;34:31–35 Assimos DG, Patterson LC, Taylor CL. Changing incidence and etiology of iatrogenic ureteral injuries. J Urol 1994;152:2240–2246 Ostrzenski A, Radolinski B, Ostrzenska KM. A review of laparoscopic ureteral injury in pelvic surgery. Obstet Gynecol Surv 2003;58:794–799 Giannakopoulos X, Lolis D, Grammeniatis E, Kotoulas K. Iatrogenic injuries to the distal ureter during gynaecologic interventions. J Urol 1995;101:69 Saidi MH, Sadler RK, Vancaillie TG et al. Diagnosis and management of serious urinary complications after major operative laparoscopy. Obstet Gynecol 1996;87:272–276 Weingertner AS, Rodriguez B, Ziane A et al. The use of JJ stent in the management of deep endometriosis lesion, affecting or potentially affecting the ureter: a review of our practice. BJOG 2008;115:1159–1164 Marcelli F, Collinet P, Vinatier D et al. Ureteric and bladder involvement of deep pelvic endometriosis. Value of multidisciplinary surgical management. Prog Urol 2006; 16:588–593 Seracchioli R, Mannini D, Colombo FM et al. Cystoscopy-assisted laparoscopic resection of extramucosal bladder endometriosis. J Endourol 2002; 16:663–666 Carmignani L, Ronchetti A, Amicarelli F et al. Bladder psoas hitch in hydronephrosis due to pelvic endometriosis: outcome of urodynamic parameters. Fertil Steril 2009;92:35–40 Bondavalli C, Dall’Oglio B, Schiavon L et al. Pathology of the gynecologic ureter: our experience. Arch Ital Urol Androl 2002;74:25–26 Chapron C, Pietin-Vialle C, Borghese B et al. Associated ovarian endometrioma is a marker for greater severity of deeply infiltrating endometriosis. Fertil Steril 2009;92:453–457 Klein RS, Cattolica EV. Ureteral endometriosis. Urology 1979; 13:477–482 Al-Khawaja M, Tan PH, MacLennan GT et al. Ureteral endometriosis: clinicopathological and immunohistochemical study of 7 cases. Hum Pathol 2008;39:954–959 Olive DL, Pritts EA. Treatment of endometriosis. N Engl J Med 2001;345:266–275 Nezhat C, Nezhat F, Nezhat CH et al. Urinary tract endometriosis treated by laparoscopy. Fertil Steril 1996;66:920–924 Dirim A, Celikkaya S, Aygun C, Caylak B. Renal endometriosis presenting with a giant subcapsular hematoma: case report. Fertil Steril 2009;92:391 Cabral Ribeiro J, Pérez García D, Martins Silva C, Ribeiro Santos A. Suburethral endometrioma. Actas Urol Esp 2007;31:153–156 Pałczyński B, Blok K, Blok R et al. Urethral obstruction caused by endometriosis. Ginekol Pol 2002;73:853–855 Chowdhry AA, Miller FH, Hammer RA. Endometriosis presenting as a urethral diverticulum: a case report. J Reprod Med 2004;49:321–323 Wu YC, Liang CC, Soong YK. Suburethral endometrioma. A case report. J Reprod Med 2003;48:204–205 Arzoz Fabregas M, Ibarz Servio L, Areal Calama J, Saladie Roig JM. Divertículos de uretra femenina. Arch Esp Urol 2004,57:381–388 Frackiewicz EJ. Endometriosis: an overview of the disease and its treatment. J Am Pharm Assoc 2000;40:645–657 Vercellini P, Barbara G, Abbiati A et al. Repetitive surgery for recurrent symptomatic endometriosis: what to do? Eur J Obstet Gynecol Reprod Biol 2009; 146:15–21 Busacca, L Fedele, S Bianchi et al. Surgical treatment of recurrent endometriosis: laparotomy versus laparoscopy. Hum Reprod 1998; 13:2271–2274 Berlanda N, Vercellini P, Fedele L. The outcomes of repeat surgery for recurrent symptomatic endometriosis. Curr Opin Obstet Gynecol 2010;22:320–325 Fedele L, Bianchi S, Zanconato G et al. Tailoring radicality in demolitive surgery for deeply infiltrating endometriosis. Am J Obstet Gynecol 2005; 193:114–117 Author information Authors and Affiliations Rights and permissions Copyright information © 2011 Springer-Verlag Italia About this chapter Cite this chapter De Nardi, P., Ferrari, S. (2011). Treatment. In: Deep Pelvic Endometriosis. Springer, Milano. https://doi.org/10.1007/978-88-470-1866-2_3 Download citation DOI: https://doi.org/10.1007/978-88-470-1866-2_3 Publisher Name: Springer, Milano Print ISBN: 978-88-470-1865-5 Online ISBN: 978-88-470-1866-2 eBook Packages: MedicineMedicine (R0)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK