Endometriosis features and dienogest tolerability in women with depression: a case-control study

Hanna Dietrich, Dietrich H, Knobel C, Chiara Knobel, Portmann L, Lea Portmann, Julian Matthias Metzler, Julian Metzler, Anne Muendane, Muendane A, Niggli A, Angela Niggli, Maria S Neumeier, Maria Susanne Neumeier, Neumeier MS, Imesch P, Patrick Imesch, Gabriele S. Merki‐Feld, Merki-Feld GS, Gabriele S Merki-Feld
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2023 · vol. 28(3) , pp. 198–204 · doi:10.1080/13625187.2023.2199899 · PMID:37132337 · W4367835364
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This case-control study found women with endometriosis and depression or psychiatric conditions experienced more dyspareunia and dyschezia, and were more likely to discontinue dienogest due to mood worsening.

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Abstract

OBJECTIVE: Primary aim of this study was to investigate endometriosis characteristics of patients with psychiatric conditions or depression. The secondary aim was to study tolerability of dienogest in this context. METHODS: This observational case-control study included endometriosis data from patients visiting our clinic from 2015-2021. We collected information from patient charts and in phone interviews based on a structured survey. Patients with surgical confirmed endometriosis were included. RESULTS: 344 patients fulfilled the inclusion criteria: n = 255 no psychiatric disorder, n = 119 any psychiatric disorder and n = 70 depression. Patients with depression (EM-D, p=.018; p=.035) or psychiatric condition (EM-P, p=.020; p=.048) suffered more often from dyspareunia and dyschezia. EM-P patients had more often primary dysmenorrhoea with higher pain scores (p=.045). rASRM stage or localisation of lesions did not differ. EM-D and EM-P patients discontinued dienogest treatment more often related to worsening of mood (p= .001, p=.002). CONCLUSION: EM-D or EM-P had a higher prevalence of pain symptoms. This could not be attributed to differences in rASRM stage or location of endometriosis lesions. Strong primary dysmenorrhoea might predispose to develop chronic pain-based psychological symptoms. Therefore, early diagnosis and treatment are relevant. Gynaecologist should be aware of the potential impact of dienogest on mood.

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Outcome instruments

rASRM

Condition tags

dysmenorrheaendometriosischronic_pelvic_paindyspareunia

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

Cited by (6)

Source provenance

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