The effect of laparoscopic ablation or danocrine on pregnancy rates in patients with stage I or II endometriosis undergoing donor insemination.
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Patients with laparoscopic-confirmed stage I or II endometriosis undergoing donor insemination had significantly lower fecundity compared to those with normal anatomy, and neither ablation nor danocrine improved pregnancy rates.
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Abstract
The effect of treatment on stages I and II endometriosis was evaluated in 61 women with laparoscopically proven disease who were undergoing therapeutic donor insemination. Only treatment cycles completed after diagnostic laparoscopy were used for analysis. To evaluate fecundity, we performed life-table analysis on 343 treatment cycles of therapeutic donor insemination in 67 patients with stage I or II endometriosis and compared it with 212 cycles in 43 patients with no female infertility factors. Average monthly fecundity and cumulative conception rates over six cycles were calculated for each group. A significant difference was found when patients with laparoscopically proven normal anatomy were compared with those with endometriosis (P = .002). The fecundity did not differ significantly between stage I and stage II endometriosis (P greater than .05). Neither ablation during laparoscopy nor medical treatment with danocrine improved the fecundity of patients with early-stage endometriosis (P greater than .05).
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Cited by (23)
- Endometriosis in Reproductive Years: ART and Endometriosis 2022
- Predictive factors for intrauterine insemination outcomes: a review 2020
- Endometriosis 2018
- ART in Endometriosis 2017
- Dynamics of nitric oxide, altered follicular microenvironment, and oocyte quality in women with endometriosis 2014
- Importance of genital endometriosis in pathogenesis of infertility 2013
- Endometriosis and Infertility – a consensus statement from <scp>ACCEPT</scp> (Australasian <scp>CREI</scp> Consensus Expert Panel on Trial evidence) 2012
- Pathophysiology of Infertility in Endometriosis 2011
- Fertility in women with minimal endometriosis compared with normal women was assessed by means of a donor insemination program in unstimulated cycles 2010
- Lipiodol fertility enhancement: two-year follow-up of a randomized trial suggests a transient benefit in endometriosis, but a sustained benefit in unexplained infertility 2007
- Endometriosis and assisted reproduction: the role for reproductive surgery? 2006
- The FLUSH Trial--Flushing with Lipiodol for Unexplained (and endometriosis-related) Subfertility by Hysterosalpingography: a randomized trial 2004
- Endometriose und Kinderlosigkeit 2004
- Endometriosis: modern surgical management to improve fertility 2003
- Endometriosis 2003
- Cycle-specific and cumulative fecundity in patients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or in vitro fertilization-embryo transfer 2002
- Endometriosis: current concepts and therapy 2002
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Health and fertility outcomes among women surgically treated for endometriosis 1997
- Laparoscopic treatment of symptomatic endometriosis 1996
- The effect of serum from infertile women with endometriosis on fertilization and early embryonic development in a murine in vitro fertilization model 1995
- Pathogenesis of Infertility in Endometriosis 1995
- Changing concepts of medical treatment of endometriosis 1993
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