Low LH (hCG) receptor concentration in ovarian follicles in endometriosis
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Granulosa cells of ovarian follicles in women with endometriosis showed lower LH (hCG) receptor concentrations compared to controls, indicating a potential failure in LH action mediation.
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Abstract
The concentration of LH (hCG) receptors in the granulosa cells of ovarian follicles was assayed in 20 patients with histologically proven endometriosis and in 6 control patients. The levels of receptors in 15 patients with ovarian endometriosis (0.48 +/- 0.46 fmol/mg protein) and in 5 patients with endometriosis without ovarian involvement (0.51 +/- 0.52 fmol/mg protein) were lower (p less than 0.01 and p less than 0.05, respectively) than in control patients (1.32 less than 0.61 fmol/mg protein). The severity of the disease was not reflected in the results. The low receptor concentration in endometriosis suggests a failure in the mechanism mediating LH action in the follicle.
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References (13)
- A study of plasma progesterone, oestradiol-17beta, prolactin and LH levels, and of the luteal phase appearance of the ovaries in patients with endometriosis and infertility via openalex
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- Endometriosis: associations with menorrhagia, infertility and oral contraceptives via openalex
- New aspects of the pathophysiology of endometriosis and associated infertility via openalex
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Cited by (9)
- Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis 2022
- A case of spontaneous abortion related to ovarian endometriosis in a Golden Retriever dog 2017
- Rezidivierende Endometriose?ein Kofaktor der vorzeitigen Menopause? 2003
- Elevated expression of tumour necrosis factor alpha in cultured granulosa cells from women with endometriosis 2000
- Pathophysiology of endometriosis-associated infertility 1999
- Immunoreactive endothelin-1 concentrations in follicular fluid of women with and without endometriosis undergoing in vitro fertilization-embryo transfer 1994
- Endometriosis as a cause of infertility 1989
- Decreased concentration of ovarian LH(hCG) receptor in polycystic ovarian disease and endometriosis 1984
- Luteinizing hormone receptor disorder in endometriosis 1984
Source provenance
- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:58:08.863946+00:00
- unpaywall
- last seen: 2026-10-13T06:25:51.201866+00:00
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