Decreased concentration of ovarian LH(hCG) receptor in polycystic ovarian disease and endometriosis

A Kauppila, Hannu Rajaniemi, Lars Rönnberg
In: Diagnosis and Management of Tubo-Uterine Factors in Infertility · 1984 · pp. 95–99 · doi:10.1007/978-94-011-7621-7_19 · W126536303
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This study measured LH(hCG) receptor concentrations in ovarian follicles and corpora lutea of patients with PCOD or endometriosis to investigate potential receptor issues contributing to infertility.

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The paper measured LH(hCG) receptor concentrations on human ovarian granulosa (follicular) cells from Graafian follicles or corpus luteum cells in patients with polycystic ovarian disease (PCOD) and in patients with endometriosis, motivated by the need for normal LH signaling despite high circulating gonadotropins in infertility. It reports decreased ovarian LH(hCG) receptor concentrations in these conditions, implying that impaired follicular membrane responsiveness to LH could contribute to unexplained infertility. A key limitation is that the text provided is only the abstract and bibliographic material, without methodological detail or quantitative results. Relevance to endometriosis: the abstract explicitly includes endometriosis as a condition often associated with unexplained infertility and tests LH(hCG) receptor concentrations in endometriosis patients.

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Abstract

Undisturbed LH action is essential for normal follicular maturation, ovulation and corpus luteum formation. In polycystic ovarian disease (PCOD), pituitary LH secretion, at least in relation to FSH secretion, is pathologically high1. There are also diseases, e.g. endometriosis2, known often to be accompanied by unexplained infertility in spite of apparently normal concentrations of circulating gonadotrophins. In such conditions the follicular membrane receptors mediating the action of LH might be at fault. For these reasons we measured the LH(hcG) receptor concentrations of the Graafian follicle or the corpus luteum cells of patients suffering from PCOD or endometriosis. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

Spellacy, W. N. (1981). Polycystic ovarian disease. Fertil. Steril., 36, 306 Dmowski, W. P. (1981). Current concepts in the management of endometriosis. Obstet. Gynecol. Ann., 10, 279 Rajaniemi, H., Rönnberg, L., Kauppila, A., Ylöstalo, P. and Vihko, R. (1980). Luteinizing hormone receptors in ovarian follicles of patients with polycystic ovarian disease. J. Clin. Endocrinol. Metab., 51, 1054 Kauppila, A., Rajaniemi, H. and Rönnberg, L. (1982), Low LH(hCG) receptor concentration in ovarian follicles in endometriosis. Acta Obstet. Gynecol. Scand., 61, 81 Rönnberg, L., Kauppila, A. and Rajaniemi, H. (1984). LH(hCG) receptor disorder in endometriosis. Fertil. Steril. (In press) Rao, Ch.V. (1982). Receptors for gonadotropins in human ovaries. In Recent Advances in Fertility Research. Part A: Developments in Reproductive Endocrinology. pp. 123–35. ( New York: Alan R. Liss ) Copman, T. L. and Adams, W. C. (1981). Ovarian gonadotropin receptor during experimental ovarian cyst formation in the rat. Biol. Reprod., 25, 115 Muse, K., Wilson, E. A. and Jawad, M. J. (1982). Prolactin hyperstimulation in response to thyrotropin-releasing hormone in patients with endometriosis. Fertil. Steril., 38, 542 McNeilly, A. S. (1980). Paradoxical prolactin. Nature (Lond.), 284, 212 Kauppila, A., Leinonen, P., Vihko, R. and Ylöstalo, P. (1982). Metoclopramide-induced hyperprolactinaemia impairs ovarian follicle maturation and corpus luteum formation in women. J. Clin. Endocrinol. Metab., 54, 955 Editor information Editors and Affiliations Rights and permissions Copyright information © 1984 MTP Press Limited About this chapter Cite this chapter Kauppila, A., Rajaniemi, H., Rönnberg, L. (1984). Decreased concentration of ovarian LH(hCG) receptor in polycystic ovarian disease and endometriosis. In: Harrison, R.F., Bonnar, J., Thompson, W. (eds) Diagnosis and Management of Tubo-Uterine Factors in Infertility. Studies in Fertility and Sterility, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7621-7_19 Download citation DOI: https://doi.org/10.1007/978-94-011-7621-7_19 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-011-7623-1 Online ISBN: 978-94-011-7621-7 eBook Packages: Springer Book Archive

Keywords

- Corpus Luteum - Ovarian Follicle - Luteinizing Hormone Receptor - Receptor Concentration - Unexplained Infertility These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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endometriosis

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