Unraveling the role of lncRNA in Endometriosis-Associated immune system Dysregulation: Exploring the intricate immunological changes and disrupted signaling pathways

Oghenemaro EF, Enwa Felix Oghenemaro, Ahmed Hjazi, Hjazi A, Ashishkumar Kyada, Farag M. A. Altalbawy, Kyada A, Deepak Nathiya, Parjinder Kaur, Nathiya D, Kaur P, Subasini Uthirapathy, Muthena Kariem, Mohit Kumar, Kariem M, M Ravi Kumar, Israa Habeeb Naser, Kumar MR, Naser IH
Human immunology · 2025 · vol. 86(2) , pp. 111248 · doi:10.1016/j.humimm.2025.111248 · PMID:39913955 · W4407162574
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This study investigated the role of long non-coding RNAs in immune system dysregulation associated with endometriosis, exploring immunological changes and disrupted signaling pathways.

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Abstract

A chronic illness known as endometriosis impacts women who are of reproductive maturity. It may be a factor in fertility problems, breast or ovarian cancer, asthma, cardiovascular illness, or pelvic pain. Studies have indicated that malfunctioning of the immune system is one of the prerequisites for the occurrence of endometrial diseases. Immune cells such as neutrophils and macrophages seem to be involved in the angiogenesis, proliferation, and invasion of endometriosis cells in a particular way. In this regard, defensive substances and cytokines secreted by immune cells impact the endometriosis milieu. Long non-coding RNAs (lncRNAs) mediate gene expression throughout the inflammatory process. According to the current studies, dysfunctional lncRNAs have been linked to several human disorders, including endometriosis. These non-coding RNAs are essential for immunological mechanisms because they regulate interactions between proteins or the capability of RNA and DNA to assemble, which plays a role in differentiation, cell migration, and the synthesis of inflammatory cytokines. Due to the brilliant role of lncRNAs in immune responses and the undeniable role of the immune system in reproduction biology, this study aimed to review the role of deregulated lncRNAs in immune system disorders and its mutual effect on endometriosis formation and development. Further study should identify the significance of lncRNAs linked to the disease via in-vitro and animal model investigations and the importance of uncharacterized lncRNAs found by endometriosis transcriptome studies.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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