Dydrogesterone and endometriosis
Non-randomised trial
OA: closed
CC0
⤵ 24 in-corpus citations
AI-generated summary
Dydrogesterone treatment of 49 endometriosis patients resulted in symptom relief for most, confirmed cures in 30/32 culdoscopies, and pregnancies in 10/19 infertile patients with minimal side effects.
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Abstract
The results are reported of the administration of dydrogesterone, 5 mg twice daily, to 49 patients with endometriosis. All but five patients were symptom-free after nine months of therapy. Most subjective symptoms had disappeared within four to eight weeks; dyspareunia usually took longer. In 30 out of 32 patients who had a culdoscopy after one or two treatment courses, a 'cure' of endometriosis was confirmed. Ten out of nineteen infertile patients became pregnant following treatment. The only side-effects were transient mastalgia and dizziness in two patients. No amenorrhoea or other disturbances of the menstrual cycle were reported.
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References (13)
- Conservative management of endometriosis via openalex
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- W1986705106 via openalex
- W2040893162 via openalex
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- W2419001698 via openalex
Cited by (24)
- A multicentre phase III study comparing efficacy & safety of novel extended-release vs. conventional formulation of Dydrogesterone in Indian patients with endometriosis 2024
- Hormonal Therapy in Endometriosis and Adenomyosis: Progestins 2022
- Dydrogesterone as an Option in the Medical Treatment of Endometriosis: A Brief Comment 2022
- Prolonged cyclical and continuous regimens of dydrogesterone are effective for reducing chronic pelvic pain in women with endometriosis: results of the ORCHIDEA study 2021
- An assessment of the efficacy and safety of dydrogesterone in women with ovarian endometrioma: An open-label multicenter clinical study 2021
- Dydrogesterone in the treatment of endometriosis: evidence mapping and meta-analysis 2021
- The current place of progestins in the treatment of endometriosis 2012
- Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms 2011
- The place of dydrogesterone in the treatment of endometriosis and adenomyosis 2009
- The Management of Chronic Pelvic Pain 2008
- Expression und Regulation von Enzymen des Östrogenmetabolismus in humanen Endometriumläsionen kultiviert in der Nacktmaus 2007
- Effective post-laparoscopic treatment of endometriosis with dydrogesterone 2007
- Current place of progestins in the treatment of endometriosis-related complaints 2001
- Endometriosis: an overview of the disease and its treatment 2000
- Progestins for symptomatic endometriosis: a critical analysis of the evidence 1997
- Changing concepts of medical treatment of endometriosis 1993
- Medical management of endometriosis 1993
- Endometriosis: medical therapy 1993
- Principles of medical therapy for endometriosis pain 1992
- Gestogens and anti-gestogens as treatment of endometriosis 1991
- Medical treatment of mild endometriosis associated with infertility 1991
- Histology and ultrastructure of human endometriotic tissues treated with dydrogesterone (Duphaston) 1987
- Endometriosis 1984
- Prostaglandin biosynthesis inhibitors and endometriosis 1979
Source provenance
- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:00:51.939714+00:00
- unpaywall
- last seen: 2026-10-13T06:25:51.201866+00:00
License: CC0
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