Endometriosis [ Abridged ]

Chalmers JA, J. A. Chalmers
Proceedings of the Royal Society of Medicine · 1968 · vol. 61(4) , pp. 360–362 · doi:10.1177/003591576806100420 · PMID:5653995 · PMC1902343 · W48496591
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Treatment of 55 endometriosis patients with norethisterone acetate and ethinyl estradiol for 4-9 months resulted in successful symptom relief in nearly two-thirds, with 12 previously infertile women achieving pregnancy and manageable side effects.

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Abstract

This is a report of 55 cases of endometriosis treated with norethisterone acetate 8 mg and ethinyl estradiol .1 mg(Anovlar 2 tablets daily) for 4 to 9 months. Out of the 55 cases in 40 the diagnosis was made on the basis of culdoscopy of laparotomy; in the remainder the diagnosis was clinical. Of the 40 cases 6 had previously undergone hysterectomy. Of the 55 women treated almost 2/3 were classified as successful with a further 9% improved. Successful cases are defined according to if the symptoms of endometriosis were relieved for at least 6 months following treatment and no other treatment was required for endometriosis. Pregnancy occurred following treatment in 12 cases all previously complaining of infertility. Side effects did not present a problem. About 2/3 of the patients complained of weight gain up to 10 kg but weight fell rapidly on completion of therapy. Nausea occurred in about 25% but did not present a problem after the second month of treatment.

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Condition tags

dyspareuniaendometriosisinfertility

MeSH descriptors

Endometriosis Estradiol Norethindrone Pseudopregnancy Castration Dyspareunia Dyspareunia Endometriosis Endometriosis Estradiol Estradiol Female Humans Hysterectomy Norethindrone Norethindrone Ovarian Cysts Ovarian Cysts Pregnancy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (8)

Cited by (4)

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