Conservative management of endometriosis

Chalmers JA, J. A. Chalmers
Proceedings of the Royal Society of Medicine · 1968 · vol. 61(4) , pp. 360–362 · doi:10.1177/003591576806100420 · PMID:5653995 · PMC1902343 · W48496591
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Treatment of 55 endometriosis patients with norethisterone acetate and ethinyl estradiol for 4-9 months resulted in successful symptom relief in nearly two-thirds, with 12 previously infertile women achieving pregnancy and manageable side effects.

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Abstract

This is a report of 55 cases of endometriosis treated with norethisterone acetate 8 mg and ethinyl estradiol .1 mg(Anovlar 2 tablets daily) for 4 to 9 months. Out of the 55 cases in 40 the diagnosis was made on the basis of culdoscopy of laparotomy; in the remainder the diagnosis was clinical. Of the 40 cases 6 had previously undergone hysterectomy. Of the 55 women treated almost 2/3 were classified as successful with a further 9% improved. Successful cases are defined according to if the symptoms of endometriosis were relieved for at least 6 months following treatment and no other treatment was required for endometriosis. Pregnancy occurred following treatment in 12 cases all previously complaining of infertility. Side effects did not present a problem. About 2/3 of the patients complained of weight gain up to 10 kg but weight fell rapidly on completion of therapy. Nausea occurred in about 25% but did not present a problem after the second month of treatment.

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Condition tags

dyspareuniaendometriosisinfertility

MeSH descriptors

Endometriosis Estradiol Norethindrone Pseudopregnancy Pseudopregnancy Castration Castration Dyspareunia Dyspareunia Dyspareunia Endometriosis Endometriosis Endometriosis Estradiol Estradiol Estradiol Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (4)

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