Association of p53 codon 72 polymorphism with endometriosis

Ammendola M, Maria Ammendola, Fulvia Gloria-Bottini, Gloria-Bottini F, F. Gloria‐Bottini, Francesco Sesti, Emilio Piccione, Bottini E, Egidio Bottini, E. Bottini
Fertility and sterility · 2007 · vol. 90(2) , pp. 406–408 · doi:10.1016/j.fertnstert.2007.06.051 · PMID:17931634 · W2031963973
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This study investigated the association between the p53 codon 72 polymorphism and endometriosis risk in a specific population.

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Abstract

OBJECTIVE: To study the association of endometriosis with p53 codon 72 polymorphism in the population of central Italy and to search for possible interaction with the PTPN22 polymorphism. DESIGN: Study of p53 and PTPN22 polymorphisms in women with endometriosis. Analysis of PTPN22 genotype distribution in relation to p53 genotypes. SETTING: Department of Obstetrics and Gynecology of the University of Rome "Tor Vergata." PATIENT(S): The study included 129 women with endometriosis and 147 controls from the Caucasian population of central Italy. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Evaluation of risk for endometriosis. RESULT(S): No significant difference in the distribution of p53 codon 72 genotypes was observed between endometriosis patients and controls. An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22. CONCLUSION(S): The negative association between the Arg/Arg genotype of p53 codon 72 found in Chinese people has not been observed in Japanese and Italian populations. Interaction with genes showing different allele frequencies among ethnic groups could be responsible for the differences reported among human populations concerning the relationship between p53 and susceptibility to endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Tumor Suppressor Protein p53 Codon Codon Endometriosis Endometriosis Female Female Humans Humans Infant, Newborn Infant, Newborn Italy Italy Polymorphism, Genetic Polymorphism, Genetic Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatase, Non-Receptor Type 22 Tumor Suppressor Protein p53

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (7)

Cited by (22)

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