Increased cyclooxygenase-2 expression is associated with better clinical outcome in patients submitted to complete ablation for severe endometriosis

Francesco Fanfani, Anna Fagotti, Fagotti A, Gabriella Ferrandina, Giuseppe Bifulco, Francesco Legge, Domenica Lorusso, Luca Minelli, Minelli L, Giovanni Scambia
Human Reproduction · 2005 · vol. 20(10) , pp. 2964–2968 · doi:10.1093/humrep/dei160 · PMID:15979990 · W2116822764
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Increased cyclooxygenase-2 expression in severe endometriosis tissue correlates with a lower risk of relapse and longer relapse-free survival after complete laparoscopic ablation.

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Abstract

BACKGROUND: Recent studies have demonstrated the overexpression of cyclooxygenase-2 (COX-2) in endometriosis. The aim of this study was to investigate the correlation between COX-2 expression and the clinical outcome rate in a homogeneous series of patients undergoing fertility-sparing complete laparoscopic ablation for severe endometriosis. METHODS: COX-2 expression was analysed by immunohistochemistry in 103 samples, 71 endometriomas (group 1) and 32 peritoneal implants and or recto-vaginal nodules (group 2) of endometriotic tissue from 85 patients submitted to complete laparoscopic ablation of severe endometriosis. RESULTS: At median follow-up of 54 months, a recurrence rate of 24.7% (n = 21) was observed. Patients with COX-2-positive endometriotic cysts showed a lower relapse rate than COX-2-negative cases (16.7 versus 41.2%; P = 0.036). Patients with COX-2-positive peritoneal implant and or recto-vaginal nodule showed a similar trend. Taking the two groups of patients together, we found a significantly lower relapse rate in COX-2-positive patients in comparison to COX-2-negative patients (16.4 versus 40%; P = 0.0152). Moreover, COX-2-positive patients showed a longer relapse-free survival in comparison to COX-2-negative patients (P = 0.016). CONCLUSIONS: In patients with severe endometriosis who underwent fertility-sparing complete ablation, COX-2 overexpression characterizes a subgroup of patients with lower risk of relapse and longer relapse-free survival.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis Endometriosis Gene Expression Regulation, Enzymologic Gene Expression Regulation, Enzymologic Adult Adult Cyclooxygenase 2 Cyclooxygenase 2 Disease-Free Survival Disease-Free Survival Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Endometrium Female Female

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