Immunosuppressive effect of danazol on lymphocyte-mediated cytotoxicity toward human endometrial stromal cells

P Viganò, Paola Viganò, A. M. Di Blasio, Di Blasio AM, M Busacca, Busacca M, Mauro Busacca, M. Vignali, Vignali M
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 1994 · vol. 8(1) , pp. 13–19 · doi:10.3109/09513599409028452 · PMID:8059612 · W2012910522
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Danazol at 5 x 10(-6) mol/l suppressed lymphocyte-mediated cytotoxicity against human endometrial stromal cells, with effects detected as early as 24 hours and increasing up to 72 hours.

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Abstract

The influence of danazol on the expression of lymphocyte-mediated cytotoxicity toward the stromal component of the endometrium was examined. Stromal cells were isolated from endometrial biopsy specimens of nine women without endometrial pathology and 12 patients with endometriosis. A cytotoxicity assay by 51Cr release was performed to determine the effect of danazol on natural killer lymphocyte lytic activity. A significant suppression of spontaneous cytotoxicity against stromal cell targets of both study subjects was observed when effectors were pretreated for 48 h with danazol at a concentration of 5 x 10(-6) mol/l. The time-course of the danazol effect indicated that drug activity was detectable as early as 24 h after the addition of the drug and increase up to 72 h. These findings confirm that danazol may influence the immune system at many levels. In particular, they demonstrate that the drug is also able to inhibit the natural immunity toward the stromal component of the endometrium.

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Condition tags

endometriosis

MeSH descriptors

Cytotoxicity, Immunologic Danazol Endometrium Immunosuppressive Agents Adult Adult Cytotoxicity, Immunologic Cytotoxicity, Immunologic Danazol Danazol Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female

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