The value of pre-treatment with gonadotrophin releasing hormone (GnRH) analogue in IVF-ET therapy of severe endometriosis
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Pre-treatment with a GnRH analogue significantly increased oocyte retrieval, embryo transfer, and clinical pregnancy rates in women undergoing IVF-ET for severe endometriosis after prior failed cycles.
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Abstract
Controversy concerning the optimal treatment of endometriosis and its related infertility still exists. Thirty-one women with moderate and severe endometriosis, who failed to conceive during previous in-vitro fertilization and embryo transfer (IVF-ET) cycles (protocol A), were re-admitted for the procedure following a period of hormonal suppression with a gonadotrophin releasing-hormone (GnRH) agonist (protocol B). Following GnRH analogue treatment, a significantly higher number of oocytes were recovered (P less than 0.0006); consequently more embryos were transferred and significantly higher clinical pregnancy rates per cycle (P less than 0.0001) were achieved. This difference may be directly related to the beneficial effect of the GnRH analogue on pelvic endometriosis, converting severe cases into mild ones with improved ovarian accessibility and probably oocyte quality.
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Cited by (38)
- Medical Management of Ovarian Endometriomas: A Systematic Review and Meta-analysis 2023
- Pretreatment with dienogest in women with endometriosis undergoing IVF after a previous failed cycle 2020
- Effect of GnRH agonist before IVF on outcomes in infertile endometriosis patients: a randomized controlled trial 2020
- Continuous oral contraceptives versus long-term pituitary desensitization prior to IVF/ICSI in moderate to severe endometriosis: study protocol of a non-inferiority randomized controlled trial 2019
- Continuous oral contraceptives versus long-term pituitary desensitization prior to IVF/ICSI in moderate to severe endometriosis: study protocol of a non-inferiority randomized controlled trial 2019
- Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies 2015
- Analogs of Luteinizing Hormone-Releasing Hormone in the Treatment of Endometriosis 2015
- Comparison of ovulation induction protocols after endometrioma resection 2014
- Endometriosis and assisted reproductive technologies: maximizing outcomes 2013
- Efficacy and safety of IVF/ICSI in patients with severe endometriosis after long-term pituitary down-regulation 2013
- Infertility Therapies: The Role of Assisted Reproductive Technologies 2011
- Endometriosis: current therapies and new pharmacological developments 2009
- Surgical Preparation of the Patient for In Vitro Fertilization 2008
- Medical Management of Endometriosis 2008
- Long-term use of gonadotropin-releasing hormone analogues before IVF in women with endometriosis 2007
- Zur Bedeutung der Endometriose in der Reproduktionsmedizin 2007
- Optimising in vitro fertilisation (IVF) outcome in women with endometriosis 2006
- Is it of value to treat endometriosis prior to IVF 2006
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2006
- Tratamento da endometriose 2006
- Ovarian stimulation for in vitro fertilization in patients with endometriosis 2004
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2004
- Medical Therapy for Endometriosis 2003
- Does Endometriosis Affect the Results of In Vitro Fertilization? 2003
- Management of endometriosis-associated infertility 2003
- Does surgical management of endometriosis within 6 months of an in vitro fertilization-embryo transfer cycle improve outcome? 2003
- Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis 2002
- Medical management of endometriosis and infertility 2000
- Effects of endometriomas on ooccyte quality, embryo quality, and pregnancy rates in in vitro fertilization cycles: a prospective, case-controlled study 1998
- Severity of endometriosis and IVF outcome 1996
- Laparoscopic treatment of symptomatic endometriosis 1996
- Endometriosis: a stage by stage analysis--the role of in vitro fertilization 1995
- Female infertility: causes and treatment 1994
- Endometriosis: medical therapy 1993
- Pretreatment with gonadotrophin releasing hormone (GnRH) analogue prior to in vitro fertilisation for patients with endometriosis 1993
- The impact of long-term gonadotropin-releasing hormone analogue treatment on preclinical abortions in patients with severe endometriosis undergoing in vitro fertilization-embryo transfer 1992
- Menotropin stimulation after prolonged gonadotropin releasing hormone agonist pretreatment for in vitro fertilization in patients with endometriosis 1992
- Transvaginal ultrasonic needle-guided aspiration of endometriotic cysts before ovulation induction for in vitro fertilization 1991
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