The Association Between Asthma and Endometriosis: A Systematic Review and Metanalysis

Maria E. Ramos‐Niño, Abraham Agaya Obadiah, Ifesinachi Ogochukwu Ozugha, Prakash V. A. K. Ramdass
In: Journal of Respiration · 2025 · vol. 5(2) , pp. 6 · doi:10.3390/jor5020006 · W4409334179
Systematic review / meta-analysis OA: gold CC0
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This meta-analysis found a significant association between asthma and endometriosis, with asthma prevalence of 14.9% in endometriosis patients versus 9.1% in controls, and an odds ratio of 1.59.

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Abstract

Observational studies suggest a comorbid link between asthma and endometriosis, but the evidence remains limited and inconsistent. This study presents a meta-analysis examining this association. A comprehensive search of literature databases was conducted through August 2024. Prevalence rates and odds ratios (ORs) were calculated to assess the relationship between asthma and endometriosis. For the prevalence analysis, sixteen studies, including 54,856 endometriosis cases and 300,613 controls, were included. The analysis yielded a prevalence of asthma in endometriosis patients of 14.9% (95% CI [10.3, 19.6], p < 0.001), with high heterogeneity (I2 = 99.9%). In the control group, asthma prevalence was 9.1% (95% CI [6.5, 11.6], p < 0.001, I2 = 99.9%). For the odds ratio (OR) analysis, twelve studies, including 295,845 endometriosis cases and 28,030,081 controls, were included. The meta-analysis demonstrated a significant association between asthma and endometriosis with an OR of 1.59 (95% CI [1.22, 2.07], p = 0.0007, I2 = 100%). Subgroup analyses stratified by study region and study type were also conducted. This meta-analysis suggests a significant association between asthma and endometriosis, indicating that common factors underlying these chronic inflammatory diseases may contribute to this comorbidity. The findings support the biological plausibility of this association.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (88)

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