Yasushi Hirota

No ORCID on file · 137 papers in corpus · active 2002-2026

Study types

  • article 106
  • other 15
  • preprint 5
  • book-chapter 4
  • review 4

Condition tags

  • endometriosis 101
  • adenomyosis 36
  • endometrioma 27
  • infertility 12
  • dysmenorrhea 8
  • mesh:D004716 2
  • thoracic_endometriosis 1
  • die_deep_infiltrating 1
  • disambig:endometritis 1
  • chronic_pelvic_pain 1
article 2019
Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2019-00281

CONTEXT: The ovarian reserve is reduced in patients with endometriosis. We hypothesize that the phosphatidylinositol 3-kinase (PI3K)-phosphatase and tensin homolog deleted on chromosome 10 (PTEN) Akt-Forkhead box O (Foxo3) pathway is involv…

article 2019
IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719119831782
article 2019
PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719119828095
article 2019
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations
Nature communications ·doi:10.1038/s41467-019-13708-y

Uterine adenomyosis is a benign disorder that often co-occurs with endometriosis and/or leiomyoma, and impairs quality of life. The genomic features of adenomyosis are unknown. Here we apply next-generation sequencing to adenomyosis (70 ind…

book-chapter 2018
Adenomyosis and Subfertility
·doi:10.1007/978-981-10-7167-6_10
article 2018
Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118806395
article 2018
Long‐term dienogest administration in patients with symptomatic adenomyosis
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13674

AIM: Adenomyosis is a common gynecological disorder that causes dysmenorrhea, hypermenorrhea and metrorrhagia. Previously, we reported that 24 weeks of dienogest treatment is highly effective for pain in symptomatic adenomyosis. Up to prese…

article 2018
The efficacy of non‐assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13826

AIM: To determine the efficacious treatment for infertile couples, we assessed the impact of infertility factors including endometriosis on assisted reproductive technology (ART) and non-ART treatment, and the effect of age in infertility t…

article 2018
Thoracic endometriosis syndrome: Comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2018.04.021
other 2017
Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.09.036

OBJECTIVES: To characterize peritoneal dendritic cells (DCs) in endometriosis and to clarify their role in its etiology. DESIGN: Experimental. SETTING: University hospital. PATIENT(S): Sixty-three women (35 patients with endometriosis an…

article 2017
Preoperative assessment of factors associated with difficulty in performing total laparoscopic hysterectomy
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13198

AIM: Our objective was to determine the preoperative factors associated with difficulty in total laparoscopic hysterectomy (TLH). METHODS: This retrospective clinical study included 157 patients who underwent TLH for leiomyoma or adenomyosi…

other 2016
Development of ovarian cancer after excision of endometrioma
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.07.1077

OBJECTIVE: To determine the prevalence rate of subsequent development of ovarian cancer after excision of endometrioma. DESIGN: Retrospective cross-sectional study. SETTING: University hospital. PATIENT(S): A total of 485 women with endo…

article 2016
Dienogest reduces nerve growth factor expression in human adenomyosis
·doi:10.1016/j.jri.2016.04.016
article 2016
Dienogest reduces nerve growth factor expression in human adenomyosis
·doi:10.1016/j.jri.2016.04.184
article 2016
Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2016.10.053
article 2016
Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells
Journal of reproductive immunology ·doi:10.1016/j.jri.2016.12.002
article 2016
Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2016-1515

CONTEXT: Endometriosis is an estrogen-dependent, chronic inflammatory disease. Recent studies have shown that vitamin D (VD) is an effective modulator of the immune system and plays an important role in controlling many inflammatory disease…

article 2016
ISP-31-9 Analgesic effects of levonorgestrel-releasing intrauterine system (LNG-IUS) on patients with and without adenomyosis(Group 31 Endometriosis,International Session Poster)
article 2016
ISP-32-3 Hysterectomy does not change recurrence rate of ovarian endometrioma after cystectomy(Group 32 Endometriosis/Endometrium,International Session Poster)
article 2016
ISP-32-5 Anti-inflammatory effects of drospirenone on endometriosis(Group 32 Endometriosis/Endometrium,International Session Poster)
article 2016
ISP-32-6 The process of endometrial reconstruction in the mouse model of decellularized matrix transplantation(Group 32 Endometriosis/Endometrium,International Session Poster)
article 2016
ISP-32-7 Hypoxia inducible factor 2α (Hif2α) regulates embryo implantation(Group 32 Endometriosis/Endometrium,International Session Poster)
article 2016
Neutrophil depletion reduces endometriotic lesion formation in mice
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12540

PROBLEM: Neutrophils are known to be accumulated in endometriosis; however, direct evidence of the impact of neutrophils in the development of endometriosis was lacking. To clarify the importance of neutrophils, we examined the effect of ne…

article 2016
Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12489

PROBLEM: Resistance to apoptosis, together with inflammatory and invasive activity, contributes to the pathogenesis of endometriosis; therefore, approaches that can safely enhance apoptosis in endometriotic tissue are highly sought after as…

article 2016
Th2 Cells and Th17 Cells in the Development of Endometriosis – Possible Roles of Interleukin-4 and Interleukin-17A
·doi:10.5301/je.5000257

Endometriosis is recognized as an inflammatory disease in which inflammatory cytokines, such as interleukin (IL)-1β and TNFα, play important roles. Immunological factors are also suggested to be involved in the pathogenesis of endometriosis…