Fan Yang

The microenvironment and cell populations within the myometrium play crucial roles in maintaining uterine structural integrity and protecting the fetus during pregnancy. However, the specific changes occurring at the single-cell level in th…

BACKGROUND: Semaphorin 3A (Sema3A) is a member of neural guidance factor family well-known for inducing the collapse of nerve cell growth cone and regulating nerve redistribution. It also has been characterized as an immunoregulatory and tu…

Observational studies have reported an association between gastroesophageal reflux disease (GERD) and endometriosis. We conducted a two-sample and bidirectional Mendelian randomization analysis to determine whether those associations are ca…

The successful establishment of endometrial receptivity is a key factor in ensuring the fertility of ewes and their economic benefits. Hu sheep have attracted attention due to their high fecundity and year-round estrus. In this study, we fo…

OBJECTIVE: To explore the role of gut dysbiosis-derived β-glucuronidase (GUSB) in the development of endometriosis (EMs). DESIGN: 16S rRNA sequencing of stool samples from women with (n = 35) or without (n = 30) endometriosis and from a mo…

The high detection rate of pulmonary subsolid nodules (SSN) is an increasingly crucial clinical issue due to the increased number of screening tests and the growing popularity of low-dose computed tomography (LDCT). The persistence of SSN s…

Endometriosis is an estrogen-dependent disease. Several researches have reported the dysregulated circular RNAs (circRNAs) in endometriosis, whereas the functions of circRNAs are largely unknown. This study aims to explore the role and mech…

Background: Endometriosis (EMS) is an estrogen-dependent disease in which endometrial glands and stroma arise outside the uterus. Current studies have suggested that the number and function of immune cells are abnormal in the abdominal flui…

Intramural pregnancy refers to the implantation of fertilized eggs in uterine musculature, separated from the uterine cavity and tube. We report a case of intramural pregnancy previously misdiagnosed as retained products of conception and g…

AIM: To study the involvement and interrelationship of epithelial cell adhesion molecule (EpCAM) and epithelial-mesenchymal transition (EMT) in endometriosis. METHODS: Samples from 114 patients undergoing endometrial biopsy or operation fo…

肝脏子宫内膜异位症是一种极为罕见的良性疾病，由于缺乏典型的临床症状、影像学和实验室检查结果，导致很难与其他肝脏囊性占位性病变相鉴别。该病确诊主要依据病理学检查和免疫组化检查，手术切除是其主要治疗方式，根据肿瘤位置、大小及有无临床症状决定是否手术。本文报道一例肝脏子宫内膜异位症患者的诊治情况，并回顾相关文献进行讨论。

PURPOSE: Recent studies have shown that abnormal distribution of pelvic nerves contributes to endometriosis-associated pain. However, the relationship between neurogenesis and pain severity in endometriosis still remains uncertain, which ma…

Primary dysmenorrhea (PDM), a significant public health problem for adolescents and young women, is characterized by painful menstrual cramps. Recent neuroimaging studies have revealed that brain functional and structural abnormalities are …

Objective:To investigate the diagnostic value of serum tumor markers carbohydrate antigen(CA125)in patients with adenomyosis.Methods:A total of 90 patients with adenomyosis and 68 healthy subjects were chosen.Serum CA125 in 2 groups was det…

Objective To evaluate the quality of life(QOL)and its influencing factors in adenomyosis-associated dysmenorrhea patients.Methods Seventy-three adenomyosis-associated dysmenorrhea patients were chosen as the case group and 90healthy women a…

Objective:The present study used the SF-36 scale to evaluate the quality of life in patients with adenomyosis dysmenorrhea by taking YiKunNeiYi pills treatment.Methods:The present study was a randomized,open-label,non-blinded clinical study…

Aurora kinase A (AURKA), a serine/threonine kinase, has been shown to regulate the cell cycle checkpoint and maintain genomic integrity. AURKA is overexpressed in various carcinomas. Breast cancer 2, early onset (BRCA2) has an important rol…

Objective:To observe the effect of QuYiKang on TXB2 and 6-Keto-PGF1αof endometriosis in rats and to study the possible therapeutic mechanism. Methods: Models of endometriosis in rats were established by operation transportation, which were …

PURPOSE: This study investigated whether the association between passive smoking exposure and primary dysmenorrhea is modified by two susceptibility genes, cytochrome P450 1A1 (CYP1A1)MspI and CYP1A1HincII. METHODS: We recruited 1645 femal…

OBJECTIVE: This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. METHODS: This report includes 1645 (1124 no dysmenorrhea, 52…

AIM: To study the pathogenesis of endometriosis(EM) by investigating cytokine(CK) and CKR genes expression involved in the development of EM. METHODS: The CK and CKR gene expression pattern in samples of EM and normal endometrial tissues w…

The expression of mRNA of Epo and VEGF in endometriosis was 3.08+-0.48 and 2.95+-0.43, respectively, which was significantly higher than those in normal endometrium (P<0.001). The expression of Epo mRNA was closely correlated with that of V…

AIM: To explore pregnancy results of infertility in endometriosis with gonadorelin release hormone analogue (GnRH A) in combination with in vitro fertilization (IVF). METHODS: In 5 patients, 3 patients suffered from adenomyosis. They were t…