Ludwig Kiesel

OBJECTIVE: To study the function of miR-145, known to be dysregulated in endometriosis, and to identify its target genes in an in vitro endometriosis model. DESIGN: Experimental laboratory study. SETTING: University medical centers. PATI…

Adult stem cells are thought to participate in endometrial regeneration during the reproductive phase of women. We have previously demonstrated dysregulated stem cell activity in endometriosis, a benign disease associated with unspecific pa…

microRNAs are small non-coding RNAs which regulate gene expression at the posttranscriptional and translational level. microRNAs have previously been demonstrated to be dysregulated in endometriosis, a hormone-dependent disease associated w…

Our laboratories have focused recently on the production and localization of eotaxin, a C-C-chemokine of 8.4 kDa, whose major biological activity is the chemoattraction of eosinophils. Given evidence of autoimmune activity in the endometrio…

Micro RNAs (miRNAs) are small non-coding RNAs which regulate numerous cellular processes at the posttranscriptional and translational level. In endometriosis, expression of miRNAs is frequently dysregulated. miRNAs are predicted to modulate…

OBJECTIVE: To study the function of syndecan-1 (SDC1) and its potential regulator miR-10b in endometriosis. DESIGN: Experimental laboratory study. SETTING: University medical center. PATIENT(S): Not applicable. INTERVENTION(S): The huma…

Expression of the pluripotency factors SOX-2, OCT-4, KLF-4, and NANOG was analyzed by quantitative real-time polymerase chain reaction, immunohistochemistry, and immunofluorescence microscopy in the endometrium, myometrium, and endometrioti…

Fragestellung: mikroRNAs sind kleine nichtcodierende RNAs, die durch Bindung an die 3'UTR-Region von Ziel-mRNAs die Genexpression regulieren. Bei der Endometriose ist das Expressionsmuster von mikroRNAs im Vergleich zum gesunden Gewebe sign…

Einleitung: mikroRNAs sind kleine nichtcodierende RNAs, die durch Bindung an die 3'UTR-Region von Ziel-mRNAs die Genexpression regulieren. Bei der Endometriose ist das Expressionsmuster von mikroRNAs im Vergleich zum gesunden Gewebe signifi…

Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potent…

To investigate the effect of medrogestone on bone mineral density (BMD) and bone turnover under conditions of estrogen withdrawal, premenopausal women with endometriosis were treated with goserelin (Zoladex), combined with either placebo (g…

A non-contraceptive benefit of oral hormonal contraceptives (OC) is a diminished risk for certain benign as well as malignant tumours, such as benign breast tumours, uterine fibroids and ovarian cysts. Endometriosis itself is not positively…

Surveys show that most women desire a change in their menstrual pattern in the sense that they would prefer less menstruations or even amenorrhea. On this behalf, there is no difference between women having spontaneous natural cycles and wo…

Adult stem cells are thought to be responsible for the high regenerative capacity of the human endometrium, and have been implicated in the pathology of endometriosis and endometrial carcinoma. The RNA-binding protein Musashi-1 is associate…

Fragestellung: Aktive nicht pigmentierte Endometrioseherde werden häufig mit entzündlichen, postentzündlichen oder unspezifischen Veränderungen des Peritoneums verwechselt bzw. gänzlich übersehen. Mit der Fluoreszenzdiagnostik steht in der …

OBJECTIVE: This study was undertaken to evaluate the feasibility of autofluorescence laparoscopy in the diagnosis of endometriotic lesions. STUDY DESIGN: Prospective analysis of 83 consecutive patients undergoing laparoscopy for suspected …

Fragestellung: Aktive nicht pigmentierte Endometrioseherde werden häufig mit entzündlichen, postentzündlichen und unspezifischen Veränderungen des Peritoneums verwechselt bzw. gänzlich übersehen. Mit der Fluoreszenzdiagnostik steht in der G…