Ludwig Kiesel

Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case-control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis.…

Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case–control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis.…

Endometriosis is characterized by growth of endometrial tissue at ectopic locations. Down-regulation of microRNA miR-200b is observed in endometriosis and malignant disease, driving tumour cells towards an invasive state by enhancing epithe…

OBJECTIVE: To study the expression and function of syndecan-4 in endometriosis. DESIGN: Histopathological investigation of eutopic endometrium and experimental laboratory study on a cell line derived from epithelial endometriotic cells (12…

STUDY QUESTION: What is the global consensus on the classification of endometriosis that considers the views of women with endometriosis? SUMMARY ANSWER: We have produced an international consensus statement on the classification of endome…

Endometriosis is an estrogen-dependent disease characterized by ectopic growth of endometrium-like glands and stroma outside the uterus. It has a considerable impact on endometrial receptivity: it is estimated, that 6%-10% of women in gener…

Einleitung: Die Endometriose ist eine Östrogen-abhängige Erkrankung, die durch das ektope Wachstum von endometriumähnlichem Stroma und Drüsen außerhalb des Uterus gekennzeichnet ist. Neben einer heterogen ausgeprägten Schmerzsymptomatik ist…

Endometriosis is associated with severe pelvic pain and reduced fertility. Recently, it has been linked to a dysregulation of microRNAs (miRNAs), which are post-transcriptional regulators of gene expression. The functional effect of dysregu…

Der Begriff Endometriose ist definiert als das Vorkommen von Endometrium oder Endometrium ähnlichem Gewebe außerhalb des Cavum uteri. (Giudice 2010) Die Syndecane sind transmembranöse Rezeptoren auf der Zelloberfläche, die für die Zelladhäs…

Read the full review for this Faculty Opinions recommended article: Endometriosis impairs bone marrow-derived stem cell recruitment to the uterus whereas bazedoxifene treatment leads to endometriosis regression and improved uterine stem cel…

PURPOSE: To evaluate the presence of a lesion indicative of endometriosis with transvaginal elastography. MATERIALS AND METHODS: Transvaginal ultrasound and clinical examination were carried out in 48 women with clinical symptoms indicativ…

Introduction: Endometriosis is a hormone-dependent disease characterized by growth of endometrial tissue at ectopic locations. Recent results indicate a dysregulation of microRNAs, small non-coding posttransciprional regulators of gene expr…

OBJECTIVE: To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of human tissues relevant to endometriosis. DESIGN: An international collaboration involv…

OBJECTIVE: To harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration. DESIGN: An international collaboration involving 34 clinical/academic centers and…

OBJECTIVE: To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of fluid biospecimens relevant to endometriosis. DESIGN: An international collaboration i…

Study question: What is the optimal management of women with endometriosis based on the best available evidence in the literature?Summary answer: Using the structured methodology of the Manual for ESHRE Guideline Development, 83 recommendat…

STUDY QUESTION: Is there a global consensus on the management of endometriosis that considers the views of women with endometriosis? SUMMARY ANSWER: It was possible to produce an international consensus statement on the current management …

In the last few years, considerable progress has been made understanding endometriosis and developing diagnostic procedures and therapeutic options. Sophisticated endoscopic instruments allow laparoscopic surgery even in progressed stages a…

microRNAs (miRNAs) are small, non-coding RNAs which regulate gene expression at the posttranscriptional and translational level. Due to their high regulatory capacity, they are capable of modulating a variety of physiological and pathophysi…