The endometrial stem cell markers notch-1 and numb are associated with endometriosis

Andreas N. Schüring, Beatrice Dahlhues, Anna Korte, Ludwig Kiesel, Ulf Titze, Birte Heitkötter, Christian Rückert, Martin Götte
2018 · doi:10.5281/zenodo.3695800 · W4289092915
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-09-11 ⓘ

This case-control study found that eutopic endometrial expression of stem cell markers Notch-1 and Numb is significantly associated with the presence and specific clinical presentations of endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-10 · read from full text ⓘ

This case-control study investigated the association between endometrial stem cell markers notch-1 and numb and the presence of endometriosis in 51 patients and 76 controls undergoing laparoscopy and biopsy. The researchers found that numb expression was significantly higher in the luminal epithelium of eutopic endometrium from endometriosis patients compared to controls, while deep infiltrating endometriosis showed significantly higher notch-1 expression in endometrial glands. These results support the hypothesis that altered stem cell marker expression in the eutopic endometrium is linked to specific clinical presentations of the disease. This paper is centrally about endometriosis — specifically examining the role of stem cell markers notch-1 and numb in its pathophysiology.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case–control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis. Fifty-one endometriosis patients and 76 controls were recruited in the IVF unit and tertiary endometriosis referral centre of a university hospital. All subjects underwent transcervical endometrial biopsy and diagnostic laparoscopy. Expression of endometrial notch-1 and numb was assessed by immunostaining and correlated with clinical data. Association of stem-cell-marker expression with the presence of endometriosis was evaluated. Numb expression in the luminal epithelium was significantly higher in eutopic endometrium of endometriosis patients compared with controls (20.5% versus 16.5%, P = 0.033). Numb-positive single stromal cells were less frequent in endometrioma patients compared with other forms of endometriosis (0.3 versus 0.5 cells/visual field; P = 0.028). Notch-1 expression in endometrial glands was significantly higher in patients with deep infiltrating endometriosis compared with controls (39.1% versus 21.8%; P = 0.045). We conclude that stem cell markers notch-1 and numb of eutopic endometrium are associated with endometriosis and its clinical presentations, supporting the stem cell hypothesis of endometriosis. These findings could help develop promising research strategies applying endometrial stem cells as novel tools.
Full text 2,232 characters · extracted from oa-doi-fallback · click to expand
The endometrial stem cell markers notch-1 and numb are associated with endometriosis Authors/Creators - 1. Department of Gynaecology and Obstetrics, University Hospital of Münster, 48149 Münster, Germany - 2. Gerhard-Domagk-Institute of Pathology, University Hospital of Münster, 48149 Münster, Germany - 3. Institute of Biometry and Statistics, University Hospital of Münster, 48149 Münster, Germany Description Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case–control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis. Fifty-one endometriosis patients and 76 controls were recruited in the IVF unit and tertiary endometriosis referral centre of a university hospital. All subjects underwent transcervical endometrial biopsy and diagnostic laparoscopy. Expression of endometrial notch-1 and numb was assessed by immunostaining and correlated with clinical data. Association of stem-cell-marker expression with the presence of endometriosis was evaluated. Numb expression in the luminal epithelium was significantly higher in eutopic endometrium of endometriosis patients compared with controls (20.5% versus 16.5%, P = 0.033). Numb-positive single stromal cells were less frequent in endometrioma patients compared with other forms of endometriosis (0.3 versus 0.5 cells/visual field; P = 0.028). Notch-1 expression in endometrial glands was significantly higher in patients with deep infiltrating endometriosis compared with controls (39.1% versus 21.8%; P = 0.045). We conclude that stem cell markers notch-1 and numb of eutopic endometrium are associated with endometriosis and its clinical presentations, supporting the stem cell hypothesis of endometriosis. These findings could help develop promising research strategies applying endometrial stem cells as novel tools. Files Preprint Version_Schüring_2018_MOMENDO.pdf Files (431.0 kB) | Name | Size | Download all | |---|---|---| | md5:dc7eebdad45be852ab537f21dc2d0e36 | 431.0 kB | Preview Download | Additional details Related works - Is cited by - 29398419 (PMID) - Is previous version of - Journal article: 10.1016/j.rbmo.2017.11.010 (DOI)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisdie_deep_infiltratingendometrioma

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK