Aberrant expression of the pluripotency marker SOX-2 in endometriosis
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This study investigated pluripotency markers in endometriosis and found aberrant SOX-2 expression in endometriotic tissue, suggesting a stem cell origin.
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Abstract
Expression of the pluripotency factors SOX-2, OCT-4, KLF-4, and NANOG was analyzed by quantitative real-time polymerase chain reaction, immunohistochemistry, and immunofluorescence microscopy in the endometrium, myometrium, and endometriotic tissue of 36 patients. Aberrant expression of SOX-2 may indicate a stem cell origin of endometriosis, whereas the presence of all progenitor markers in endometrial tissue marks the endometrium as a potential source for induced pluripotent stem cell generation.
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- europepmc
- last seen: 2026-06-23T06:15:44.889181+00:00
- pubmed
- last seen: 2026-05-13T22:17:00.782903+00:00
- unpaywall
- last seen: 2026-06-23T06:35:03.149509+00:00
License: public-domain-us
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine