Ming-Tsung Lai (493834)

No ORCID on file · 16 papers in corpus · active 2015-2022

Study types

  • dataset 8
  • other 7
  • article 1

Condition tags

  • endometriosis 16
  • infertility 3
dataset 2022
Dominant and recessive effects of five functional SNPs in UCA1 between Taiwanese endometriosis patients and controls1.
·doi:10.1371/journal.pone.0271616.t002

Dominant and recessive effects of five functional SNPs in UCA1 between Taiwanese endometriosis patients and controls1.

dataset 2022
Genotypic and allelic distributions of five functional SNPs in UCA1 between Taiwanese endometriosis patients and controls1.
·doi:10.1371/journal.pone.0271616.t001

Genotypic and allelic distributions of five functional SNPs in UCA1 between Taiwanese endometriosis patients and controls1.

other 2022
Haplotype analyses of selected functional SNPs in UCA1 and their associations with clinical features of endometriosis patients.
·doi:10.1371/journal.pone.0271616.g001

Odds ratios and 95% confidence intervals of three risk haplotypes based on clinical features, including (A) CA125 levels; (B) disease stage; (C) pain score; and (D) endometriosis-associated infertility.

dataset 2022
Haplotype frequencies of selected SNPs in UCA1 gene between endometriosis patient and controls1.
·doi:10.1371/journal.pone.0271616.t003

Haplotype frequencies of selected SNPs in UCA1 gene between endometriosis patient and controls1.

other 2022
Proposed pathogenesis model in the development of endometriosis and the associated infertility based on the findings of this study.
·doi:10.1371/journal.pone.0271616.g008

Elevated UCA1 in endometriosis patients via RNA stabilization by functional SNPs can disrupt lipogenesis regulation by sponging key miRNAs with target genes involved in lipid metabolism. Such epigenetic regulation can further lead to reduce…

dataset 2021
Dominant and recessive effects of the selected SNPs in HOTAIR gene between Taiwanese endometriosis patients and controls.
·doi:10.1371/journal.pone.0248168.t002

Dominant and recessive effects of the selected SNPs in HOTAIR gene between Taiwanese endometriosis patients and controls.

article 2021
Functional impacts of endometriosis-related risk alleles (SNPs at rs1838169, rs4511324 and rs17720428) on HOTAIR RNA structure.
·doi:10.1371/journal.pone.0248168.s005
dataset 2021
Genotypic and allelic distributions of six functional SNPs in HOTAIR gene between Taiwanese endometriosis patients and controls.
·doi:10.1371/journal.pone.0248168.t001

Genotypic and allelic distributions of six functional SNPs in HOTAIR gene between Taiwanese endometriosis patients and controls.

dataset 2021
Haplotype frequencies of selected SNPs in HOTAIR gene between endometriosis patients and controls.
·doi:10.1371/journal.pone.0248168.t003

Haplotype frequencies of selected SNPs in HOTAIR gene between endometriosis patients and controls.

other 2021
Haplotypes of endometriosis-related SNPs in HOTAIR and their associations with clinical features.
·doi:10.1371/journal.pone.0248168.g001

Two-allele genetic combinations among three endometriosis-related SNPs in HOTAIR, including rs1838169, rs4511324 and rs17720428, were analyzed in patients and correlated with the frequencies of (A) high CA125 levels (> 35.0 U/ml); (B) sever…

other 2021
HOTAIR expression and its association with endometriosis development.
·doi:10.1371/journal.pone.0248168.g003

Microarray data (GSE120103) from the GEO databank was utilized for clinical association study. (A) HOTAIR levels in lesions from severe endometriosis patients (stage 4) (Endo; n = 18) were analyzed and compared with that in normal endometri…

other 2021
Schematic summary of a proposed model depicting functional impacts of HOTAIR genetic variations on endometriosis development.
·doi:10.1371/journal.pone.0248168.g005

Genetic variations at SNP sites, rs1838169 (C to G) and rs17720428 (T to G), in HOTAIR are frequently detected in patients with endometriosis. Such genetic substitutions alter thermo-stability of mature HOTAIR and stabilize its RNA structur…

dataset 2015
Association between haplotypes of rs1970801 and rs1434536 in BMPR1B with endometriosis and CA125 level in patients.
·doi:10.1371/journal.pone.0080630.t003

aGenotype and allele distributions were analyzed by χ2 test.

dataset 2015
Genotype and allele distributions of SNPs surrounding miRNA target site of BMPR1B in endometriosis patients and controls.
·doi:10.1371/journal.pone.0080630.t001

aGenotype and allele distributions were analyzed by χ2 test.Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval.

other 2015
Genotypic variants presented at miR-125b binding site correlated with varied CA125 levels in patients.
·doi:10.1371/journal.pone.0080630.g002

A. Serum CA125 levels in endometriosis patients were grouped by their rs1434536 genotypes. Bold lines indicate median values of CA125 levels in each genotype group. Notch regions define 95% confidence interval estimations of median values. …

other 2015
Schematic representation of a proposed model depicting functional influences of genetic variations in BMPR1B 3′UTR on endometriosis development.
·doi:10.1371/journal.pone.0080630.g004

Mature miRNAs including miR-125b are produced by several processing steps where the microprocessor complex (Drosha/DGCR8), exportin 5 and Dicer/TRBP/PACT complex have been known to involve in. The resulting miR-125b forms a RISC complex wit…