Genotypic variants presented at miR-125b binding site correlated with varied CA125 levels in patients.

Cherry Yin-Yi Chang (493833), Yi Chen (38576), Ming-Tsung Lai (493834), Hui-Wen Chang (209955), Jack Cheng (493835), Carmen Chan (493836), Chih-Mei Chen (309456), Shan-Chih Lee (493837), Ying-Ju Lin (419103), Lei Wan (290406), Pei-Wen Tsai (227589), Su-Han Yang (493838), Ching Chung (493839), Jim Jinn-Chyuan Sheu (493840), Fuu-Jen Tsai (230856)
2015 · doi:10.1371/journal.pone.0080630.g002 · W6885622496
other OA: green CC0
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-09 ⓘ

This study correlated rs1434536 genotypes with varied CA125 levels in endometriosis patients and analyzed BMPR1B and CA125 expression in ectopic endometrial tissues.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-07 · read from full text ⓘ

This study investigates the association between genotypic variants at the miR-125b binding site and serum CA125 levels in patients with endometriosis. Researchers analyzed serum samples grouped by rs1434536 genotypes and measured gene expression of BMPR1B and CA125 in ectopic endometrial tissues using quantitative PCR and immunohistochemistry. The results indicated that specific genetic variations correlated with altered CA125 levels and BMPR1B up-regulation, defining susceptibility to the condition. This paper is centrally about endometriosis — specifically examining how a miRNA binding site variant influences BMPR1B expression and associated CA125 biomarker levels in affected patients.

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Abstract

A. Serum CA125 levels in endometriosis patients were grouped by their rs1434536 genotypes. Bold lines indicate median values of CA125 levels in each genotype group. Notch regions define 95% confidence interval estimations of median values. B. Gene expression levels of BMPR1B and CA125 (MUC16) in ectopic endometrial tissues were measured by quantitative PCR for correlation study. C. Immunohistochemistry (IHC) staining was performed on ectopic endometrial tissues from patients. Anti-CD10 staining, a stroma cell-specific marker, serves as the reference to normalize immunointensity. Ectopic endometrium samples represented patients with rs1434536 genotype of CC, CT; and TT, as labeled on top of each column. A total of 6, 8 and 12 samples from tissue microarrays could be defined as TT, CT and CC genotype groups, respectively, and their expression levels for BMPR1B and CA125 were scored as described in method section (right panel). Box plot and ANOVA P value calculation were performed in R software suite.
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BMPR1B Up-Regulation via a miRNA Binding Site Variation Defines Endometriosis Susceptibility and CA125 Levels Figure 2 Genotypic variants presented at miR-125b binding site correlated with varied CA125 levels in patients. A. Serum CA125 levels in endometriosis patients were grouped by their rs1434536 genotypes. Bold lines indicate median values of CA125 levels in each genotype group. Notch regions define 95% confidence interval estimations of median values. B. Gene expression levels of BMPR1B and CA125 (MUC16) in ectopic endometrial tissues were measured by quantitative PCR for correlation study. C. Immunohistochemistry (IHC) staining was performed on ectopic endometrial tissues from patients. Anti-CD10 staining, a stroma cell-specific marker, serves as the reference to normalize immunointensity. Ectopic endometrium samples represented patients with rs1434536 genotype of CC, CT; and TT, as labeled on top of each column. A total of 6, 8 and 12 samples from tissue microarrays could be defined as TT, CT and CC genotype groups, respectively, and their expression levels for BMPR1B and CA125 were scored as described in method section (right panel). Box plot and ANOVA P value calculation were performed in R software suite.

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