Haplotype analyses of selected functional SNPs in UCA1 and their associations with clinical features of endometriosis patients.

Cherry Yin-Yi Chang (7224650), Li Yang (6520), Joe Tse (13170672), Lun-Chien Lo (10262918), Chung-Chen Tseng (10262915), Li Sun (4624), Ming-Tsung Lai (493834), Ping-Ho Chen (540958), Tritium Hwang (10262924), Chih-Mei Chen (309456), Fuu-Jen Tsai (230856), Jim Jinn-Chyuan Sheu (7326185)
2022 · doi:10.1371/journal.pone.0271616.g001 · W6885953356
other OA: green CC0
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-12 ⓘ

This study investigated three risk haplotypes within UCA1 and their associations with CA125 levels, disease stage, pain scores, and endometriosis-associated infertility in patients.

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⚙ AI-generated deep summary by gpt-5.6-luna, 2026-08-12 · read from full text ⓘ

The paper examined whether haplotypes formed by selected functional single-nucleotide polymorphisms in the long noncoding RNA UCA1 were associated with clinical characteristics among patients with endometriosis. Haplotype odds ratios and 95% confidence intervals were evaluated in relation to CA125 levels, disease stage, pain scores, and endometriosis-associated infertility, with the proposed biological context involving UCA1’s miRNA-sponge activity and regulation of lipogenesis. The presented analysis identified three risk haplotypes, although the available text does not provide detailed participant characteristics, effect estimates, or explicitly stated limitations. This paper is centrally about endometriosis — evaluating UCA1 genetic haplotypes in relation to disease severity, symptoms, and associated infertility.

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Abstract

Odds ratios and 95% confidence intervals of three risk haplotypes based on clinical features, including (A) CA125 levels; (B) disease stage; (C) pain score; and (D) endometriosis-associated infertility.
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Genetic variations in UCA1, a lncRNA functioning as a miRNA sponge, determine endometriosis development and the potential associated infertility via regulating lipogenesis Fig 1 Haplotype analyses of selected functional SNPs in UCA1 and their associations with clinical features of endometriosis patients. Odds ratios and 95% confidence intervals of three risk haplotypes based on clinical features, including (A) CA125 levels; (B) disease stage; (C) pain score; and (D) endometriosis-associated infertility.

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endometriosisinfertility

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