Haplotypes of endometriosis-related SNPs in HOTAIR and their associations with clinical features.

Cherry Yin-Yi Chang (7224650), Chung-Chen Tseng (10262915), Ming-Tsung Lai (493834), An-Jen Chiang (688755), Lun-Chien Lo (10262918), Chih-Mei Chen (309456), Man-Ju Yen (10262921), Li Sun (4624), Li Yang (6520), Tritium Hwang (10262924), Fuu-Jen Tsai (230856), Jim Jinn-Chyuan Sheu (7326185)
2021 · doi:10.1371/journal.pone.0248168.g001 · W6904628887
other OA: green CC0
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The paper examines combinations of three endometriosis-related HOTAIR SNPs—rs1838169, rs4511324, and rs17720428—and their association with clinical characteristics in patients with endometriosis. Haplotypes were correlated with elevated CA125 levels, severe pain, advanced disease stages (III–IV), and infertility, although the provided text does not report the specific associations or effect estimates. Interpretation is limited because only a figure description is available, without details on cohort size, statistical methods, or study limitations. This paper is centrally about endometriosis — it evaluates HOTAIR genetic haplotypes in relation to disease severity, symptoms, biomarker levels, and infertility.

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Abstract

Two-allele genetic combinations among three endometriosis-related SNPs in HOTAIR, including rs1838169, rs4511324 and rs17720428, were analyzed in patients and correlated with the frequencies of (A) high CA125 levels (> 35.0 U/ml); (B) severe pain (pain score > 5.0); (C) advanced stages (stages 3 and 4); and (D) infertility.
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Genetic impacts on thermostability of onco-lncRNA HOTAIR during the development and progression of endometriosis Fig 1 Haplotypes of endometriosis-related SNPs in HOTAIR and their associations with clinical features. Two-allele genetic combinations among three endometriosis-related SNPs in HOTAIR, including rs1838169, rs4511324 and rs17720428, were analyzed in patients and correlated with the frequencies of (A) high CA125 levels (> 35.0 U/ml); (B) severe pain (pain score > 5.0); (C) advanced stages (stages 3 and 4); and (D) infertility.

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endometriosisinfertility

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