HOTAIR expression and its association with endometriosis development.

Cherry Yin-Yi Chang (7224650), Chung-Chen Tseng (10262915), Ming-Tsung Lai (493834), An-Jen Chiang (688755), Lun-Chien Lo (10262918), Chih-Mei Chen (309456), Man-Ju Yen (10262921), Li Sun (4624), Li Yang (6520), Tritium Hwang (10262924), Fuu-Jen Tsai (230856), Jim Jinn-Chyuan Sheu (7326185)
2021 · doi:10.1371/journal.pone.0248168.g003 · W6904523153
other OA: green CC0
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-08 ⓘ

This study analyzed HOTAIR and associated gene expression in severe endometriosis lesions compared to normal endometria to understand its role in disease development.

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⚙ AI-generated deep summary by gpt-5.6-luna, 2026-08-12 · read from full text ⓘ

The study used GEO microarray data (GSE120103) to examine HOTAIR expression in severe stage 4 endometriosis lesions from 18 patients compared with normal endometrium from 18 controls. It also assessed expression of genes in HOTAIR-associated PRC2 and LSD1/REST/CoREST complexes, as well as possible downstream targets at the HOXD locus and other validated genes, using t-tests. The analysis was limited to a small, publicly available dataset and to severe disease, with the provided text not reporting the direction or magnitude of the observed expression differences. This paper is centrally about endometriosis — evaluating HOTAIR and related molecular pathways in endometriosis development.

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Abstract

Microarray data (GSE120103) from the GEO databank was utilized for clinical association study. (A) HOTAIR levels in lesions from severe endometriosis patients (stage 4) (Endo; n = 18) were analyzed and compared with that in normal endometria (Normal; n = 18). (B) Expression levels of component genes in HOTAIR-associated complexes, PRC2 and LSD1/REST/CoREST, were also analyzed and compared with the levels in healthy controls. (C) Expression levels of possible downstream effectors of HOTAIR, including genes at the HOXD locus and other validated targets [17,28], were compared between patients (Endo) and controls (Normal) by using t-test.
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Genetic impacts on thermostability of onco-lncRNA HOTAIR during the development and progression of endometriosis Fig 3 HOTAIR expression and its association with endometriosis development. Microarray data (GSE120103) from the GEO databank was utilized for clinical association study. (A) HOTAIR levels in lesions from severe endometriosis patients (stage 4) (Endo; n = 18) were analyzed and compared with that in normal endometria (Normal; n = 18). (B) Expression levels of component genes in HOTAIR-associated complexes, PRC2 and LSD1/REST/CoREST, were also analyzed and compared with the levels in healthy controls. (C) Expression levels of possible downstream effectors of HOTAIR, including genes at the HOXD locus and other validated targets [17,28], were compared between patients (Endo) and controls (Normal) by using t-test.

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endometriosis

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