Association between haplotypes of rs1970801 and rs1434536 in BMPR1B with endometriosis and CA125 level in patients.

Cherry Yin-Yi Chang (493833), Yi Chen (38576), Ming-Tsung Lai (493834), Hui-Wen Chang (209955), Jack Cheng (493835), Carmen Chan (493836), Chih-Mei Chen (309456), Shan-Chih Lee (493837), Ying-Ju Lin (419103), Lei Wan (290406), Pei-Wen Tsai (227589), Su-Han Yang (493838), Ching Chung (493839), Jim Jinn-Chyuan Sheu (493840), Fuu-Jen Tsai (230856)
2015 · doi:10.1371/journal.pone.0080630.t003 · W6941755966
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This study analyzed genotype and allele distributions of BMPR1B haplotypes rs1970801 and rs1434536 to investigate their association with endometriosis and CA125 levels in patients.

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This study investigated the genetic association between specific haplotypes of the BMPR1B gene, namely rs1970801 and rs1434536, and the risk of endometriosis in patients. The researchers analyzed how variations in these loci influence BMPR1B expression through miRNA binding site changes and correlated these genetic factors with serum CA125 levels. Results indicated that certain haplotypes were significantly associated with increased susceptibility to endometriosis and altered CA125 concentrations, suggesting a potential molecular mechanism for disease pathogenesis. This paper is centrally about endometriosis — specifically examining the genetic susceptibility markers and biomarker levels associated with the condition.

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Abstract

aGenotype and allele distributions were analyzed by χ2 test.
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BMPR1B Up-Regulation via a miRNA Binding Site Variation Defines Endometriosis Susceptibility and CA125 Levels Table 3 Association between haplotypes of rs1970801 and rs1434536 in BMPR1B with endometriosis and CA125 level in patients. Skip to main content Advertisement Browse Subject Areas ? Click through the PLOS taxonomy to find articles in your field. For more information about PLOS Subject Areas, click here. Association between haplotypes of rs1970801 and rs1434536 in BMPR1B with endometriosis and CA125 level in patients.

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endometriosis

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