Chen W

AIMS: This study aims to develop and validate a Multi-Dimensional Computational Screening (MDCS) strategy to identify bioactive components by jointly considering target affinity, exposure potential, and safety, using Liangdi decoction (LDD)…

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a rare histological subtype of ovarian cancer, often associated with endometrial lesions, and characterized by poor prognosis and a high propensity for recurrence and metastasis. This study…

BackgroundAtrial fibrillation (AF) and ovarian cancer are leading causes of morbidity, with emerging evidence suggesting potential interplay. However, their temporal and genetic relationships remain unclear.MethodsWe analyzed 265,248 women …

OBJECTIVES: To investigate the relationship between lesion stiffness and symptoms of patients and to evaluate the effectiveness of high-intensity focused ultrasound ablation (HIFUa) against lesion stiffness and symptoms of patients with ade…

Adenomyosis (ADM) is a benign condition associated with various gynecological disorders. However, effective treatment options are limited, highlighting the urgent need for novel therapeutic targets. This study identified abnormal activation…

ETHNOPHARMACOLOGICAL RELEVANCE: Gonadotropin-releasing hormone agonists (GnRH-a) often induce menopausal symptoms, negatively affecting women's psychological, emotional, and physical health. Kuntai capsule is widely used in clinical practic…

BACKGROUND: The concept of ferroptosis debuted as a newly defined programmed cell death in 2012. Among programmed cell death mechanisms, ferroptosis stands out as being fundamentally dependent on iron. At the heart of this mechanism lies th…

ObjectivesThis study investigated the protective effects and mechanisms of rhaponticin (Rha) against acinar cell injury in acute pancreatitis (AP).MethodsPancreatic acinar cell injury was induced using multiple in vitro and in vivo AP model…

BACKGROUND: Multiple myeloma (MM) in association with pregnancy is a rare event, and a consensus is lacking. It is urgent to increase the awareness of investigations required for a suspected diagnosis of MM during pregnancy and optimise its…

BackgroundHepatocellular carcinoma (HCC) mainly develops in cases of fibrosis and cirrhosis and is accompanied by intestinal flora disorder. HCC also affects CD8+ T cell immune function. 5,7-Dimethoxyflavone (DMF), an active flavonoid with …

BACKGROUND: Long-acting Gonadotropin-releasing hormone analogs(GnRHa), including leuprolide, goserelin, histrelin, buserelin, triptorelin, have been widely used for a variety of diseases including prostate cancer, breast cancer, endometrios…

BackgroundPelvic floor surface electromyography (sEMG) is widely used to evaluate and treat pelvic floor dysfunctions (PFDs). Based on sEMG, the Glazer protocol was developed over 20 years ago with a limited sample size, making it challengi…

BACKGROUND: The abdominal wall is one of the rare sites of endometriosis, and its clinical incidence is increasing year by year with the increasing cesarean section rate nowadays. METHODS: A retrospective analysis was made on patients with…

The microbiota of the female genital tract is crucial for reproductive health. This study aims to investigate the impact of the lower genital tract microbiota on in vitro fertilization and frozen embryo transfer (IVF-FET) outcomes. This stu…

Few studies explored air pollution's role in female infertility, especially with temperature factors. Investigating these effects is essential given global climate change and declining fertility rates. This retrospective study, conducted in…

BACKGROUND: Endometriosis (EM) is a chronic gynecological disorder characterized by the growth of endometrial-like tissue outside the uterus, leading to pain and infertility. Recent studies suggest that antioxidants may play a protective ro…

BACKGROUND: Endometriosis is an estrogen-dependent inflammatory disease that is the leading cause of dysmenorrhea, infertility, and pelvic pain in women. A growing body of evidence has demonstrated that platelets may play an important role …

PurposeTo investigate BMAL1 and BMP6 expressive differences in ovarian granulosa cells (OGCs) of patients with polycystic ovary syndrome (PCOS), explore regulatory relationship, assess their impacts on OGC proliferation and apoptosis, and a…

Endometriosis is a complex, chronic inflammatory gynecological disorder with estrogen‑dependent characteristics that severely impairs the quality of life of women and potentially leads to infertility. However, its pathogenesis remains poorl…

Thoracic endometriosis syndrome is a rare form of endometriosis in which endometrial tissue is thought to migrate to the lungs and, with the onset of menstruation, the ectopic foci bleed, causing a range of pulmonary manifestations. In this…

ObjectiveTo investigate the efficacy of the Er Zhi Tian Gui Formula (EZTGF) in diminished ovarian reserve (DOR) patients undergoing in vitro fertilization-embryo transfer (IVF-ET); to examine the pharmacological mechanism of EZTGF in inhibi…

ObjectivesThe aim of this study was to assess the clinical outcomes of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in patients with breast fibroadenoma (FA) of different sizes.Materials and methodsA total of 88 patients …

PurposeThis study aimed to compare the efficacy of human chorionic gonadotropin (hCG) and dual-trigger (gonadotropin-releasing hormone agonist [GnRH-a] and hCG) protocols in terms of cumulative live birth rate (CLBR) and other pregnancy out…