Journal of ovarian research

BACKGROUND: The adnexal region in females presents complex imaging due to the menstrual cycle. Accurate diagnosis is crucial for effective tumor treatment. This study aims to assess the clinical utility of abnormal adnexal uptake on 68Ga-FA…

BACKGROUND: Trends toward earlier age at menarche, the starting point in women’s reproductive lifespan, have been observed globally. Whether an earlier age at menarche influences Anti-Müllerian hormone (AMH), a clinical indicator of ovarian…

OBJECTIVE: Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by reproductive and metabolic abnormalities. This study aimed to identify key immunometabolic regulators in endometrial tissue and construct a …

BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent and heterogeneous endocrine disorder and a leading cause of female infertility. Impaired oocyte maturation in PCOS patients undergoing in vitro fertilization (IVF) adversely affect…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common disorder affecting the reproductive, endocrine, and metabolic systems in women. Dysfunction of granulosa cells (GCs) and imbalance of the immune microenvironment are key pathological …

Ovarian cancer remains a highly lethal malignancy, with advanced-stage diagnosis, recurrence, and chemoresistance, thus limiting clinical outcomes. Traditional biomarkers such as CA-125, BRCA1/2 status, and histopathology offer only a parti…

BACKGROUND: The integration of artificial intelligence (AI) into reproductive medicine and gynecologic oncology has driven transformative advances in the diagnosis, prognosis, and management of ovarian conditions, including malignancies, en…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and a major cause of anovulatory infertility, often requiring assisted reproductive technology (ART). The freeze-all strategy followed by frozen-thawed embryo tr…

BACKGROUND: Prolonged menstrual cycles may indicate potential cardiometabolic conditions; however, there are limited data on how these associations vary among women without polycystic ovary syndrome (PCOS) undergoing in vitro fertilization …

BACKGROUND: The 2023 International Federation of Gynecology and Obstetrics (FIGO) staging system introduced Stage IA3 to categorize a subset of synchronous endometrial and ovarian carcinomas (SEOC) with favorable outcomes. This study aims t…

BACKGROUND: In mammals, precise regulation of primordial follicle activation is essential for maintaining the female reproductive lifespan. In this study, we demonstrated that the vitamin D receptor (VDR) is expressed in both pre-granulosa …

Female infertility, accounting for 40–50% of infertility cases globally, underscores the urgent need for non-invasive biomarkers to guide early intervention. Cell-free DNA (cfDNA)—released via apoptosis, necrosis, or active secretion—has em…

Ceramide, a central hub in sphingolipid metabolism, serves as a critical bioactive signalling mediator that integrates lipid metabolism with multiple signalling pathways, primarily promoting autophagy and apoptosis. It influences female rep…

BACKGROUND: Ovarian endometriotic cysts represent a prevalent form of endometriosis and are typically identifiable via imaging modalities. Nonetheless, differentiating endometriotic cysts from other benign non-endometriotic ovarian cysts, s…

OBJECTIVE: Polycystic ovary syndrome (PCOS) is a leading cause of female infertility, and early pregnancy outcomes in affected women are affected by multiple interactive factors; however, no well-established predictive tools are available. …

BACKGROUND: The clinical association between female reproductive disorders, such as endometriosis, polycystic ovary syndrome(PCOS), uterine leiomyoma, and female infertility and psychiatric disorders, such as major depressive disorder(MDD),…

BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the second most lethal gynecologic malignancy, often diagnosed at a late stage due to the lack of reliable early detection strategies. Currently, there are no specific diagnostic or pr…

BACKGROUND: Polycystic ovary syndrome (PCOS) has been associated with adverse pregnancy outcomes; however, current literature presents inconsistent findings, probably due to varying feotal numbers included in previous research. This study s…

OBJECTIVE: This study reports a rare case of mixed ovarian carcinoma composed of squamous cell carcinoma (SCC) and high-grade serous carcinoma (HGSC) arising from endometriosis, and provides a systematic review of the relevant literature. …

BACKGROUND: Endometriosis is a common cause of infertility and is frequently associated with recurrent implantation failure in assisted reproductive technologies. Impaired endometrial receptivity, mediated by altered transcription factors, …

BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder with reproductive, metabolic, and psychological features, often underdiagnosed due to diagnostic inaccuracies and inconsistent knowledge among providers. These gaps hi…

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by chronic low-grade inflammation of the ovaries. This disorder of the immune microenvironment is closely related to abnormal follicular development and ovulation disorders. This…

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in women during their reproductive years and is associated with a wide range of reproductive, metabolic, and psychological complications. This review aims to …

Ovarian aging, marked by a progressive diminution of oocyte quality and quantity, is a major contributor to declining female fertility and age-related reproductive disorders. However, transcript-level changes underlying this process remain …