Journal of ovarian research

BACKGROUND: Homocysteine (Hcy) is a sulfur-containing intermediate metabolite during methionine metabolism. Studies indicate that individuals with polycystic ovary syndrome (PCOS) have higher circulating Hcy levels relative to unaffected po…

BACKGROUND: Early detection of epithelial ovarian cancer (EOC) is hampered by the absence of an ideal serum biomarker. This study aimed to further validate the utility of IgG Gal-ratio in pre-operative diagnosis of ovarian cancer. METHODS: …

BACKGROUND: In vitro maturation (IVM) presents a potential alternative to conventional IVF for special subgroups of infertile couples. Anti-Müllerian Hormone (AMH) is widely regarded as the most robust biomarker for assessing ovarian reserv…

QUESTION: To investigate the impact of autoimmune thyroiditis (AIT) on IVF/ICSI outcomes in patients with polycystic ovary syndrome (PCOS) and chronic endometritis (CE). DESIGN: This retrospective cohort study analyzed 444 oocyte retrieval…

BACKGROUND: Oral contraceptive pills (OCPs) are widely used for symptom control in women with ovarian endometrioma; however, their impact on ovarian reserve and the optimal duration of treatment remain uncertain, particularly for women plan…

BACKGROUND: The coagulation-section of the mesosalpinx during the salpingectomy can lead to injuries on the ovarian vascularization, and thus to the ovarian response to hormonal stimulation. Does salpingectomy affect negatively the follicle…

OBJECTIVE: To perform a preliminary, hypothesis-generating evaluation of the association between intraovarian injection of platelet-rich plasma (PRP) combined with peripheral blood mononuclear cells (PBMCs) and ovarian response parameters i…

BACKGROUND: There is a clear need for new approaches to help women with low ovarian reserve. A new intervention for women with low ovarian reserve is the intra-ovarian injection of platelet-rich plasma (PRP). It is important to comprehensiv…

BACKGROUND: Inflammation has been linked to female fertility, yet its impact on ovarian reserve and response remains unclear. This study investigates the associations between systemic inflammatory markers, ovarian reserve—assessed by anti-M…

BACKGROUND: Predicting in vitro fertilization (IVF) pregnancy outcomes is crucial for individualized decision-making. However, due to complex interactions among multiple factors, accurate manual integration and assessment are challenging. T…

Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder with a complex and yet unresolved etiology. Although ovulation induction therapy can improve ovulatory function, the natural pregnancy rate and pregnancy outco…

Premature ovarian insufficiency (POI), particularly chemotherapy-induced ovarian failure (CIOF), severely compromises the reproductive and endocrine health of young women. Current fertility-preserving strategies, such as cryopreservation an…

BACKGROUND: This study aims to use non-targeted metabolomics to analyze the metabolic characteristics of follicular fluid in patients with decreased ovarian reserve (DOR) and explore the mediating role of these metabolites in DOR and assist…

BACKGROUND: Diminished ovarian reserve (DOR) is associated with impaired female fertility; however, its molecular mechanisms remain incompletely understood. Our previous studies found that individuals with DOR have lower levels of microRNA-…

BACKGROUND: Irregular sleep and eating patterns in modern lifestyles may disrupt reproductive rhythms, thereby impairing reproductive function in adult women. In livestock production, improper management may disturb livestock eating and act…

BACKGROUND: This study investigates the clinical characteristics, treatment strategies, and prognosis of ovarian leiomyoma, with the goal of enhancing diagnostic accuracy and therapeutic outcomes for this rare condition. METHODS: We retrosp…

BACKGROUND: Ovarian preservation in premenopausal patients with endometrial cancer remains challenging due to the potential presence of concurrent adnexal malignancy. To support surgical decision-making, we developed an interpretable machin…

Ovarian cancer remains one of the most lethal gynecological malignancies, with borderline ovarian tumors (BOTs) representing lesions of low malignant potential requiring distinct surgical management. Accurate preoperative differentiation be…

BACKGROUND: Primary peritoneal clear cell carcinoma (PPCCC) is an exceptionally rare malignancy that closely resembles gynecologic epithelial cancers clinically and histologically. Its pathogenesis is poorly understood, with possible origin…

BACKGROUND: In clinical practice, repeated oocyte retrieval cycles are often necessary for patients with diminished ovarian reserve (DOR). It has been hypothesized that the mechanical stimulation from the initial oocyte pick-up (OPU) proced…

Age-related fertility decline is an increasingly important challenge in reproductive medicine, driven largely by progressive ovarian aging. The aging ovary undergoes functional deterioration characterized by reduced ovarian reserve and decl…

Endometriosis-associated ovarian cancer (EAOC), encompassing subtypes like ovarian clear cell (OCCC) and endometrioid (OEC) carcinoma, represents a distinct Type I malignancy arising from endometriotic lesions. These tumors are characterize…

BACKGROUND: Polycystic ovary syndrome (PCOS) is closely associated with systemic low-grade inflammation, yet evidence regarding erythrocyte sedimentation rate (ESR), a cost-effective and stable inflammatory marker, in reproductive-aged wome…

PURPOSE: Accurate prognostic prediction remains a significant challenge in the management of low-grade serous ovarian cancer (LGSOC), a rare and molecularly distinct histologic subtype. This study aimed to develop a prediction model visuali…

BACKGROUND: The long noncoding RNA (lncRNA) FAM83H-AS1 plays a critical role in the development and progression of various cancers. This study evaluates the feasibility of serum FAM83H-AS1 as a diagnostic and staging marker for ovarian canc…