Eleftherios Pierre Samartzis

INTRODUCTION: Many women with endometriosis turn to digital sources for information. Meanwhile, large language models (LLMs) appear capable of offering health advice. This study aimed to evaluate the potential in answering endometriosis-rel…

G protein-coupled estrogen receptor (GPER) has been found to be an important key regulator in the homeostasis of sex hormone-dependent human cells. The aim of this study was to compare the expression of GPER, estrogen receptor alpha (ER-α),…

INTRODUCTION: Endometriosis is an inflammatory condition, affecting mainly women of reproductive age. Leptin is a regulator of food intake and energy expenditure, posing pleiotropic actions, and regulating immunity and fertility. The aim of…

BACKGROUND: Endometriosis, the presence of endometrial-like tissue outside the uterus, is a common clinical entity between women of reproductive age, with a prevalence of about 10%. Due to the variety of endometriosis-associated symptoms, a…

Abstract: Endometriosis is a benign gynecologic condition affecting up to one woman out of ten of reproductive age. It is defined by the presence of endometrial-like tissue in localizations outside of the uterine cavity. It often causes sym…

BACKGROUND: Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor i…

Endometriosis, a painful disorder associated with infertility, is estimated to occur in approximately 7-10% of reproductive age women. Although endometriosis is considered as an estrogen-dependent disease, the role of estrogen metabolites v…

Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis s…

BACKGROUND: The G protein-coupled estrogen receptor (GPER) is thought to be involved in non-genomic estrogen responses as well as processes such as cell proliferation and migration. In this study, we analyzed GPER expression patterns from e…

Endometriose, definiert als das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb des Cavum uteri, ist eine häufige Ursache für chronische Unterbauchschmerzen, Dysmenorrhö und Sterilität. Insbesondere die medikamentös…

Endometriose, definiert als das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb des Cavum uteri, ist eine häufige Ursache für chronische Unterbauchschmerzen, Dys menorrhö und Sterilität. Insbesondere die medikamentö…

Endometriose ist eine facettenreiche Erkrankung an der weltweit ungefähr 176 Mio. Frauen leiden. Die Erkrankung definiert sich durch das Vorhandensein und Proliferieren von endometriumartigem Gewebe ausserhalb Cavum uteri, wobei die Ätiopat…