The expression of histone deacetylase 1, but not other class I histone deacetylases, is significantly increased in Endometriosis

Eleftherios Pierre Samartzis, Aurelia Noske, Nicolas Samartzis, Daniel Fink, Patrick Imesch
2013 · doi:10.5167/uzh-80794 · W6948552498
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Histone deacetylase 1, but not HDAC-2 or -3, showed significantly increased expression in endometriosis compared to normal endometrium and correlated with steroid hormone receptor expression.

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This study used a tissue microarray to analyze expression of class I histone deacetylases (HDACs 1–3) in 74 endometriosis samples and 30 normal endometrium controls, assessing protein expression by immunoreactivity scoring. Mean HDAC-1 immunoreactivity score was significantly higher in endometriosis than in normal endometrium (7.6 ± 2.5 vs 5.3 ± 2.3; P < .001), whereas HDAC-2 and HDAC-3 immunoreactivity scores were not meaningfully different between groups. A major limitation is that the work is based on observational tissue expression measures rather than functional assays of how HDAC expression changes cell behavior. This paper is centrally about endometriosis — it reports significantly increased HDAC1 expression in endometriosis tissue compared with normal endometrium.

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Abstract

Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis samples and 30 normal endometrium controls. The mean HDAC-1 immunoreactivity score (IRS ± standard deviation) was 7.6 ± 2.5 in endometriosis and 5.3 ± 2.3 in normal endometrium (P < .001). In contrast, the IRSs of HDAC-2 and -3 were 11.7 ± 0.7 and 11.8 ± 1.1 in endometriosis and 11.6 ± 1.0 and 11.9 ± 0.4 in normal endometrium (P = .7 and P = .2), respectively. Significant correlations were found between HDAC-1 and estrogen (-alpha/-beta) and progesterone receptor expression. In conclusion, HDAC-1, but not HDAC-2/-3, was significantly increased in endometriosis and associated with steroid hormone receptor expression that may reflect interdependence. In context with the literature, specific inhibitors of HDAC-1 may have inhibitory activities similar to those of broad-spectrum HDAC inhibitors and may be clinically tolerated, which would increase their chance as an option in the treatment of endometriosis.
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Abstract

Abstract

Abstract

Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis samples and 30 normal endometrium controls. The mean HDAC-1 immunoreactivity score (IRS ± standard deviation) was 7.6 ± 2.5 in endometriosis and 5.3 ± 2.3 in normal endometrium (P < .001). In contrast, the IRSs of HDAC-2 and -3 were 11.7 ± 0.7 and 11.8 ± 1.1 in endometriosis and 11.6 ± 1.0 and 11.9 ± Additional indexing Creators (Authors) Volume Volume Volume Number Number Number Page range/Item number Page range/Item number Page range/Item number Page end Page end Page end Item Type Item Type Item Type Dewey Decimal Classifikation Dewey Decimal Classifikation Dewey Decimal Classifikation Language Language Language Publication date Publication date Publication date Date available Date available Date available ISSN or e-ISSN ISSN or e-ISSN ISSN or e-ISSN OA Status OA Status OA Status Publisher DOI Citations Samartzis, E. P., Noske, A., Samartzis, N., Fink, D., & Imesch, P. (2013). The expression of histone deacetylase 1, but not other class I histone deacetylases, is significantly increased in Endometriosis. Reproductive Sciences, 20, 1416–1422. https://doi.org/10.1177/1933719113488450

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