Daniel Escorsim Machado

Estrogen exerts its effects through binding to its receptor and with the assistance of cofactors such as GREB1. Polymorphisms in the gene encoding this protein (GREB1) are potential biomarkers of susceptibility and prognosis for endometrios…

Estrogen exerts its effects through binding to its receptor and with the assistance of cofactors such as GREB1. Polymorphisms in the gene encoding this protein (GREB1) are potential biomarkers of susceptibility and prognosis for endometrios…

INTRODUCTION/OBJECTIVE: Endometriosis is a chronic inflammatory disease with limited therapeutic options and frequent adverse effects. This study aimed to develop and evaluate cerium oxide nanoparticles (nanoceria) as a potential therapeuti…

Objective: rs1137100 polymorphisms in the painful symptoms of endometriosis in Brazilian women. Methods: A retrospective study was carried out in two Brazilian public hospitals with 237 cases of endometriosis, divided into two comparison gr…

During the last decades, the cannabinoid research for therapeutic purposes has been rapidly advancing, with an ever-growing body of evidence of beneficial effects for a wide sort of conditions, including those related to mucosal and epithel…

A endometriose é uma doença ginecológica multifatorial estrogênio-dependente, caracterizada pela presença de endométrio funcional fora da cavidade uterina. Estima-se que, atualmente, cerca de 20% das mulheres da população mundial em idade f…

Abstract Objectives: to review studies that used case-control design to verify the association of polymorphisms in VEGF and KDR genes in the development of endometriosis. Methods: the systematic review selected articles published until Sept…

Abstract Objectives: to describe the epidemiological and clinical profile of women with endometriosis and to determine the association with the prognostic characteristics of the disease. Methods: retrospective descriptive study involving 23…

This study aimed to analyse the effects of clotrimazole (CTZ) on estrogen production pathway in endometriosis progression. Experimental endometriosis was induced by autologous transplantation in female Wistar rats, and then the rats were tr…

Abstract Objectives: to describe the epidemiological and clinical profile of women with endometriosis and to determine the association with the prognostic characteristics of the disease. Methods: retrospective descriptive study involving 23…

Endometriosis is a complex and heterogeneous disease in which extrinsic and intrinsic factors, such as genetics, provide to the disease development. Genome-wide association (GWA) studies may be essential to recognize genetic variants associ…

OBJECTIVES: This study aimed to evaluate the potential role of the PTGS2 single nucleotide polymorphisms (SNPs) -1195 A>G and +8473 T>C in endometriosis' development, and characterizing their association with the prognostic features of the …

Graphene is one of the crystalline forms of carbon, along with diamond, graphite, carbon nanotubes, and fullerenes, and is considered as a revolutionary and innovating product. The use of a graphene-based nanolabels is one of the latest and…

Endometriosis has a complex and multifactorial pathology, and it is considered one of the main causes of infertility nowadays. The angiogenic process, which involves remodeling of extracellular matrix, is crucial for the development of this…

The present work aimed to evaluate molecular, angiogenic and inflammatory changes induced by clotrimazole (CTZ) on endometriosis lesions. For this, thirty female Wistar rats with surgically implanted autologous endometrium were treated with…

Endometriose e a presenca de endometrio fora da cavidade uterina estimada em afetar 10% das mulheres na idade reprodutiva. Apesar de ser uma doenca benigna, muitas vezes se comporta com agressividade de doenca maligna. Os medicamentos exist…

Purpose To evaluate the magnitude of the association of the polymorphisms of the genes PGR, CYP17A1 and CYP19A1 in the development of endometriosis. Methods This is a retrospective case-control study involving 161 women with endometriosis (…

OBJECTIVE: Endometriosis is a multifactorial gynecological disease, whose pathogenesis is crucially dependent on angiogenesis, which is signaled via vascular endothelial growth factor (VEGF) and its receptor (VEGFR2). We hypothesize that si…

Role of vascular endothelial growth factor polymorphisms (−2578C> C, +405G> C and +936C> T polymorphisms between endometriosis cases and controls. A total of six haplotypes Perini et al. BMC Women's Health 2014, 14:117