Role of cytochrome P450 2C19 polymorphisms and body mass index in endometriosis: A case–control study

Cardoso JV, Jéssica Vilarinho Cardoso, Abrão MS, Maurício Simões Abrão, Plínio Tostes Berardo, Berardo PT, Ferrari R, Renato Ferrari, Nasciutti LE, Luiz Eurico Nasciutti, Daniel Escorsim Machado, Machado DE, Jamila Alessandra Perini
European journal of obstetrics, gynecology, and reproductive biology · 2017 · vol. 219 , pp. 119–123 · doi:10.1016/j.ejogrb.2017.10.027 · PMID:29102810 · W2767012655
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⚙ AI-generated summary by claude@2026-07, 2026-07-19 ⓘ

This case-control study found that the CYP2C19*2 polymorphism is associated with endometriosis, and that body mass index interacts with this polymorphism to increase risk.

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Abstract

ObjectiveTo investigate the contribution of CYP2C19 polymorphisms and body mass index (BMI) in the development of endometriosis.Study designThis is a case-control study that includes 356 women (187 cases and 169 controls) recruited from two hospitals in the Brazilian public health system. The genotyping analyses of the CYP2C19*2 and CYP2C19*17 polymorphisms were performed using TaqMan allelic discrimination assays, and the association of the studied polymorphisms with endometriosis was evaluated by multivariate logistic regression. Pearson correlation coefficients were used to investigate the interaction between BMI and CYP2C19 polymorphisms.ResultsThe variant allele frequencies of CYP2C19*2 were significantly different between cases and controls, and after adjusting for confounding factors, the CYP2C19*2 polymorphism was more frequent in women with endometriosis, considering all cases (CYP2C19*2: OR=1.83; 95% CI=1.17-2.85) and only deeply infiltrating endometriosis (DIE) cases (CYP2C19*2: OR=2.32; 95% CI=1.42-3.77). BMI was significantly lower in endometriosis patients (26.5±4.68) than in controls (27.8±5.65, P<0.02). Among obese women (BMI 30-40), the CYP2C19*2 polymorphism had a greater association with endometriosis (CYP2C19*2: OR=3.27; 95% CI=1.55-6.89). There was a positive correlation between CYP2C19*2 and BMI 30-40 (P=0.004).ConclusionsThe findings of our study suggest that CYP2C19*2 is positively associated with endometriosis and that BMI may have a significant interaction with CYP2C19*2 and the risk of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cytochrome P-450 CYP2C19 Endometriosis Adult Body Mass Index Case-Control Studies Cytochrome P-450 CYP2C19 Endometriosis Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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