Akihiko Sekizawa

Background: A tubo-ovarian abscess (TOA) is an inflammatory mass involving the fallopian tube, ovary, and occasionally the other adjacent pelvic organs. These abscesses are found most commonly in women of reproductive age and are typically …

To probe the mechanism of the development of ovarian cancer from endometriosis, which is a multistep process that involves the activation of oncogenes and inactivation of tumor suppressor genes, we evaluated p53 mutations in solitary endome…

Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA an…

OBJECTIVES: To clarify the role of specific genetic alterations in the multi-step process of malignant transformation of endometriosis. METHODS: In cases of ovarian endometrioid carcinoma, we separated regions of normal endometriosis, atypi…

Endometriosis is considered to be a possible precancerous disease. Pathologically, we observed malignant transformation of endometriosis to clear cell carcinoma or endometriotic carcinoma of the ovary, via the step of atypical endometriosis…

Several genetic alterations have been associated with the malignant transformation from endometriosis to ovarian cancer. However, the role of each genetic alteration in this multi-step process of tumorigenesis has not been clarified. Region…