Disappearance of steroid hormone dependency during malignant transformation of ovarian clear cell cancer

Akahane T, Tomoko Akahane, Sekizawa A, Akihiko Sekizawa, Tsuyoshi Okuda, Okuda T, Miki Kushima, Kushima M, Hiroshi Saito, Saito H, Takashi Okai, Okai T
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2005 · doi:10.1097/01.pgp.0000165173.90339.a2 · PMID:16175084
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This study observed a gradual reduction in estrogen and progesterone receptor expression during malignant transformation from endometriosis to ovarian clear cell carcinoma, suggesting a loss of hormone dependency.

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Abstract

Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA and OEMC specimens containing endometriosis and atypical endometriosis. Pathological progression from endometriosis to atypical endometriosis to carcinoma was identified in 4 of 22 OCCAs and 4 of 16 OEMCs. Using paraffin-embedded tissue samples, expression and changes in expression for estrogen receptors (ERs) and progesterone receptors (PRs) were examined in relation to the observed pathological changes. A gradual reduction in ERalpha and PRA expression was observed with malignant transformation from endometriosis to atypical endometriosis to OCCA. In OEMC, ERalpha expression increased with malignant transformation. In conclusion, reductions in ERalpha and PRA expression were observed with progression from endometriosis to atypical endometriosis in OCCA specimens. Disappearance of hormone dependency might therefore be associated with malignant transformation to OCCA.
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Disappearance of Steroid Hormone Dependency During Malignant Transformation of Ovarian Clear Cell Cancer - Tomoko Akahane - Akihiko Sekizawa - Tsuyoshi Okuda - Miki Kushima - Hiroshi Saito - Takashi Okai Summary: Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA and OEMC specimens containing endometriosis and atypical endometriosis. Pathological progression from endometriosis to atypical endometriosis to carcinoma was identified in 4 of 22 OCCAs and 4 of 16 OEMCs. Using paraffin-embedded tissue samples, expression and changes in expression for estrogen receptors (ERs) and progesterone receptors (PRs) were examined in relation to the observed pathological changes. A gradual reduction in ERα and PRA expression was observed with malignant transformation from endometriosis to atypical endometriosis to OCCA. In OEMC, ERα expression increased with malignant transformation. In conclusion, reductions in ERα and PRA expression were observed with progression from endometriosis to atypical endometriosis in OCCA specimens. Disappearance of hormone dependency might therefore be associated with malignant transformation to OCCA.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Ovarian Neoplasms Ovarian Neoplasms Receptors, Estrogen Receptors, Progesterone Adenocarcinoma, Clear Cell Animals Antibodies, Monoclonal Cell Transformation, Neoplastic Endometriosis Endometriosis Erb-b2 Receptor Tyrosine Kinases Erb-b2 Receptor Tyrosine Kinases Estrogen Receptor alpha Estrogen Receptor alpha Female Humans Immunohistochemistry Ki-67 Antigen

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europepmc
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pubmed
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