Bernhard Krämer

Introduction After puberty, at least 10% of all women and girls suffer from endometriosis. Surgery is useful for both the diagnosis and therapy. To date, quality indicators for the surgical treatment of endometriosis are lacking. QS ENDO ai…

Introduction Endometriosis significantly reduces patients' quality of life and is additionally a burden on healthcare and social security systems. There are currently no quality indicators for the treatment of endometriosis. The care of pat…

Als schwerste Manifestationsform der Endometriose stellt die tief infiltrierende Endometriose das Behandlungsteam oft vor besondere Herausforderungen. Neben einer möglichst exakten Diagnostik und Befundeinschätzung ist eine individuelle, an…

Objective Multiple forms of endometriosis have been shown to harbour somatic cancer-driver alterations. Previous studies have focused on the inter-patient heterogeneity of genetic alterations in endometriosis, analyzing lesions collected fr…

OBJECTIVE: To assess the diagnostic performance of preoperative application of the Enzian classification (cEnzian) using surgical findings as reference standard. DESIGN: A prospective international non-interventional study. SETTING: Twelve …

Abstract Introduction Surgical experience and hospital procedure volumes have been associated with the risk of severe complications in expert centers for endometriosis in France. However, little is known about other certified units in Centr…

Laparoscopic extensive myomectomy, hysterectomy for large myomas, laparoscopic treatment of endometriosis or treatment of cancer of the uterus are advanced laparoscopic gynaecological procedures. Since they can be very challenging, many spe…

A 52-year old female patient was referred to our tertiary center due to left sided abdominal pain radiating to the left flank 3 months after abdominal surgery of extended deep endometriosis (rASRM Stage IV) with right adnexectomy, left salp…

Neben dem Schmerz ist unerfüllter Kinderwunsch das zweite wesentliche und für die Patientin belastende Leitsymptom der Endometriose. Daher ist bei Kinderlosigkeit, insbesondere ohne Beschwerden, eine sorgfältige Abklärung sinnvoll. Wenn End…

Endometriosis has yielded controversy on whether it constitutes a single disease or distinct types. Current classification systems poorly correlate with the severity of symptoms and do not provide prognostic tools that can guide management …

Endometriosis affects a significant number of young premenopausal women. Quite apart from the medical challenges, endometriosis is a relevant burden for healthcare and social security systems. Standardized quality indicators for the treatme…

Zielsetzung Die chirurgische Therapie ist der Goldstandard in der Behandlung der TIE. Diese ist die anspruchsvollste und damit am schwierigsten zu behandelnde Endometrioseform. Unsere Untersuchung verfolgte das Ziel, den postoperativen Verl…

DIE is the most challenging type of endometriosis and may be associated with severe pain and infertility. Complete minimally invasive resection is the gold standard treatment, leading to pain relief and increased fertility in a high number …

The clinical presentation of endometriosis is highly heterogeneous. In a landmark study we have shown somatic cancer-driver mutations in deep infiltrating endometriosis, with at least one case having multiple sites harboring the same driver…

Endometriosis is a common gynecological disease and precursor of clear cell and endometrioid ovarian carcinomas. We recently demonstrated that one form of endometriosis with little malignant potential, deep infiltrating endometriosis (DE), …

STUDY QUESTION: Does incisional endometriosis (IE) harbor somatic cancer-driver mutations? SUMMARY ANSWER: We found that approximately one-quarter of IE cases harbor somatic-cancer mutations, which commonly affect components of the MAPK/RAS…

DIE is the most challenging type of endometriosis and laparoscopic surgery is considered gold standard. In order to achieve a complete resection extensive surgical procedures have to be performed in the majority of DIE patients. The aim of …