Iatrogenic endometriosis harbors somatic cancer-driver mutations

Vivian Lac, TH Praetorius, Lisanne Verhoef, Rosalía Aguirre-Hernández, TM Nazeran, Basile Tessier‐Cloutier, Natasha L. Orr, Heather Noga, J Khattra, Martin Köebel, HM Horlings, F. Kommoss, SY Brucker, J Pasternak, P. Yong, DG Huntsman, Stefan Kommoss, Michael S. Anglesio, Bernhard Krämer
In: Geburtshilfe und Frauenheilkunde · 2018 · doi:10.1055/s-0038-1671405 · W2899303935
article OA: closed CC0 ⤵ 10 in-corpus citations
View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study examined incisional endometriosis and found that it harbors somatic cancer-driver mutations, similar to deep infiltrating endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study investigated whether iatrogenic endometriosis, specifically incisional endometriosis (IE), and deep infiltrating endometriosis (DE) contain somatic cancer-driver mutations by macrodissecting archival specimens from 40 women with IE and 36 with DE and using a hypersensitive cancer hotspot sequencing panel with droplet digital PCR validation. Somatic cancer-driver events were found in 27.5% of IE and 38.9% of DE cases, with hotspot mutations reported in KRAS, ERBB2, PIK3CA, and CTNNB1. PTEN loss occurred at similar heterogeneous rates in both groups, while ARID1A loss was observed only in one DE case. The paper limits its scope to forms of endometriosis considered unlikely to transform and does not assess eutopic endometrium or endometriomas directly. This paper is centrally about endometriosis — it shows somatic cancer-driver mutations in iatrogenic (incisional) and deep infiltrating endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a common gynecological disease and precursor of clear cell and endometrioid ovarian carcinomas. We recently demonstrated that one form of endometriosis with little malignant potential, deep infiltrating endometriosis (DE), harbours recurrent somatic cancer-driver mutations. The prevalence of these mutations in other forms of endometriosis is not known. We sought to investigate this by examining other forms of endometriosis unlikely to undergo transformation. Particularly, we examined an iatrogenic form of endometriosis (incisional endometriosis; IE) where the uterine origin of cells is well accepted.

My notes (saved in your browser only)

Condition tags

endometriosisdie_deep_infiltrating

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (10)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK