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ObjectiveUterine anomalies are associated with higher rate of infertility, spontaneous abortion, premature birth and endometriosis. We report our experience in 13 cases with uterine malformations a...

Objective Uterine anomalies are associated with higher rate of infertility, spontaneous abortion, premature birth and endometriosis. We report our experience in 13 cases with uterine malformations and endometriosis. Methods The medical file…

Protein kinase B (PKB/Akt), a serine/threonine kinase, regulates the function of many cellular proteins involved in apoptosis and proliferation. It was postulated that there is a higher Akt activity in endometriosis compared with normal end…

ObjectiveRecent studies reported that endometriosis could behave as a neoplasmatic process. The purpose of this study is to investigate the family risk of ovarian, colon and prostate cancer in women with endometriosis.Study designA search o…

Endometriosis, a disease of reproductive-age women, is defined by the identification of aberrant growth of endometrial glands or stroma in sites outside of the uterine cavity. Endometriosis is a spectrum of disease spanning from minimal dis…

Endometriosis, defined as the presence of endometrial tissue outside the uterus, is a challenging condition associated with substantial morbidity. Management of endometriosis must be individualized according to the desired treatment outcome…

This chapter illustrates the different opinions regarding the pathophysiology and management of endometriosis-associated infertility. Pelvic inflammation due to endometriosis may cause adhesion formation and scarring, which leads to a disru…

Age, BMI, lifestyle, menstrual status and obstetric history can modulate the endocrine system and, therefore, have been hypothesised to play a role in in-vitro fertilisation (IVF) outcome. We designed a retrospective study, set in a medical…

CONTEXT: Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside of the uterine cavity, causing pelvic pain and infertility in 10% of reproductive-aged women. It is unclear why ectopic endo…

ObjectiveTo investigate the familial aggregation and the risk of endometriosis among the female relatives of women with endometriosis. We also compared the epidemiologic characteristics of women with and without family history of endometrio…

Endometriosis is an estrogen-dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5-5% in fertile and 25-40% in infertile women. …

Endometriosis is found in up to 60% of women with dysmenorrhea, 40-50% of reproductive age women with pelvic pain or deep dyspareunia, and 30-40% of women with infertility.1 Endometriosis is defined as the presence and proliferation of endo…

BACKGROUND: Ezrin protein and its activated form phospho-ezrin play a role in cell morphology, motility and adhesiveness. In this study, we hypothesized that these proteins play a role in the pathogenesis of endometriosis by promoting adhes…

ObjectiveFew studies examining the association of endometriosis with the risk of breast cancer. Our goal was to investigate the familial risk of breast cancer in women with endometriosis.DesignRetrospective study.SettingUniversity-based end…

Implantation is a complex process by which the embryo attaches to the endometrium. The human endometrium becomes receptive to the embryo during the luteal phase of the menstrual cycle under the influence of steroid hormones and paracrine fa…

ObjectiveThe association between demographic factors, menstrual and reproductive characteristics, and clinical profile for women with endometriosis was analyzed in a retrospective case-control study.MethodsOver a 6-year period, 535 women wi…

PURPOSE OF REVIEW: This review discusses current diagnostic techniques for müllerian anomalies, reproductive outcome data, and management options in reproductive-age women. RECENT FINDINGS: Multiple retrospective studies have investigated r…

Many chemokines likely contribute to the pathogenesis of endometriosis. The authors hypothesize that the broad-spectrum chemokine inhibitor NR58-3.14.3 may prevent ectopic human endometrium implantation and growth. After placing human endom…

ObjectiveTo investigate the response to controlled ovarian hyperstimulation and ART outcomes in women with advanced-stage endometriosis and previous surgeries at the Yale IVF program between 1996 and 2002.DesignRetrospective case control st…

A 42-year-old woman with Stage IA, grade 3 clear cell ovarian carcinoma arising within an endometrioma after multiple ovarian stimulation attempts was a unique case from a total of 900 patients who underwent laparoscopy for infertility and …

ObjectiveTo investigate the expression of interleukin-8 (IL-8) receptors CXCR1 and CXCR2 in adenomyosis.DesignComparative immunohistochemical study.SettingAcademic medical center.Patient(s)Thirty women who had undergone hysterectomy and wer…

BACKGROUND: Women with endometriosis who are treated with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) have a lower pregnancy rate compared to women with tubal factor infertility. It has been suggested that the ad…

ObjectiveTo investigate the expression of p16, retinoblastoma (pRb), and cyclin D1 oncoproteins in endometriomas and adenomyosis.DesignImmunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endome…

Human endometrium is a dynamic tissue under the influence of numerous hormones, growth factors, and cytokines interacting to maintain a balance of cellular growth, differentiation, and apoptosis. We have previously demonstrated that several…

ObjectiveTo determine whether women with hydrosalpinx would have diminished endometrial HOXA10 expression and whether salpingectomy would reverse HOXA10 suppression. The homeobox gene HOXA10 is a transcription factor that is necessary for e…