Ludwig Kiesel

Zielsetzung: Im eutopen Endometrium bestehen erhebliche menstruationszyklusabhängige Fluktuationen der Angiogenese, ein Prozess, der auch bei der Entstehung von Endometrioseläsionen beobachtet wird. Wir untersuchten hier den Einfluss hormon…

Endometriosis is a multifactorial disease affecting up to 15% of women of reproductive age. This condition is characterized by the presence and growth of endometrial cells outside the uterus. Susceptibility to endometriosis depends on compl…

Der Zusammenhang zwischen der Ausprägung der Endometriose, der Lokalisation im Bereich des kleinen Beckens und dem klinischen Erscheinungsbild ist immer noch unklar. Das Ziel der vorliegenden Arbeit ist es, die Ausdehnung sowie die typische…

(2002). Molecular mechanisms contributing to the pathogenesis of endometriosis. Gynecological Endocrinology: Vol. 16, No. 6, pp. 493-504.

Click to increase image sizeClick to decrease image sizeENDOMETRIOSIS PATHOGENESIS CYTOKINES HOX ANGIOGENESIS

Die Erkrankung Endometriose stellt sowohl in Bezug auf die noch unvollständig geklärte Entstehung und Pathogenese, als auch im Hinblick auf die diagnostische Beurteilung und adäquate Therapie eine große Herausforderung dar. Im eutopen Endom…

ObjectiveTo investigate microvessel density in adenomyosis compared to the endometrium in patients with adenomyosis and in normal controls.DesignUterine paraffin-embedded histologic specimens were immunostained for CD34. The area with the h…

Our laboratories have focused recently on the production and localization of eotaxin, a C-C-chemokine of 8.4 kDa, whose major biological activity is the chemoattraction of eosinophils. Given evidence of autoimmune activity in the endometrio…

The assessment of the activity of endometriosis provides a challenge during endoscopic procedures. Novel approaches can be developed in future based on more detailed understanding of the mechanisms of the pathogenesis of endometriosis. Angi…

Add-back hormone replacement therapy has been shown to alleviate some of the hypo-oestrogenic side effects associated with gonadotrophin-releasing hormone agonists, including demineralisation of bone. Studies on patients with uterine fibroi…

We studied the pharmacokinetics of iv and intranasally administered buserelin, a LHRH agonist peptide, in 14 women with endometriosis. Serum and urinary buserelin concentrations were determined by specific RIA (buserelin antiserum AS-639). …

In a randomized study, the effect of gestrinone (2 x 2.5 mg/week) was compared with the effect of danazol (3 x 200 mg/day) in treating 30 patients with laparoscopically proven endometriotic implants for 6 months. Therapy was effective in 80…

In vivo, a single dose of 1000 mg danazol was given orally to pregnant volunteers (n = 8) prior to a therapeutic abortion (8th-12th week of gestation). Changes in serum progesterone and estradiol were evaluated both by analysis of percentag…

In vitro, danazol showed a slight dose-dependent inhibition of the mitochondrial cholesterol side chain cleavage enzyme isolated from early gestational (8th to 12th week of gestation) placenta. In the presence of 100 microM danazol, the enz…