Okada H
No ORCID on file
· 22 papers in corpus
· active 1979-2022
Study types
- article 10
- other 5
- review 2
Condition tags
- endometriosis 15
- adenomyosis 2
- dysmenorrhea 1
Top journals
Frequent coauthors
- Hidetaka Okada 17
- Tsurusaki T 11
- Yoshimura T 8
- Teruhiko Tamaya 7
- Jiro Fujimoto 4
- Fujimoto J 4
- Kakita-Kobayashi M 4
- Kitawaki J 4
- Jo Kitawaki 3
- Motoyama T 3
2022
Introductionand importance: Postpartum retroperitoneal hematomas are a potential complication of childbirth. The management of secondary infections of such hematomas has not been fully elucidated. We present a typical case of such managemen…
2021
Introductionand importance Postpartum retroperitoneal hematoma is a birth canal injury that is difficult to diagnose because of its invisibility. Secondary infections of these hematomas are rare, and their diagnostic and management strategi…
2020
AimThe study aimed to elucidate the glycolytic metabolism of human endometrial stromal cells (hESCs) in hypoxic environment.Main methodsThe hESCs were cultured in hypoxic environment, and their metabolic pathways were analyzed using metabol…
2020
Small-cell neuroendocrine carcinoma (NEC) of the endometrium is an extremely rare and highly aggressive carcinoma. Sex-determining region Y-box 2 (SOX2) is a master transcription factor regulating the self-renewal, maintenance of stem cell …
2020
BackgroundApproximately one-third of Japanese couples currently worry or previously worried about infertility. To develop strategies for the primary prevention of infertility as a population approach, it is important for the general populat…
article
2020
We herein report two patients with endometriosis in the cecum. Both patients presented with a protruding, subepithelial tumor on colonoscopy and were diagnosed with cecal endometriosis after surgical resection. It is notable that the cecal …
other
2016
Recent evidence points to a possible role for hypoxia-inducible factor (HIF)-1 in the pathogenesis and development of endometriosis. The objectives of this study were to investigate the critical role of HIF-1 in endometriosis and the effect…
review
2011
This review describes studies on drug discovery using a rational formulation design and innovative, drug delivery systems (DDS) for biomaterials such as therapeutic peptides and nucleotides. The microcapsules of the LH-RH superagonist leupr…
article
2001
Dienogest is a synthetic steroid that has been used as a progestogen in contraceptive pills and is currently being studied for its possible clinical use in the treatment of endometriosis. In this study, we investigated the direct effects of…
article
1993
ObjectiveTo investigate steroidogenesis in eutopic and ectopic endometrial tissues in adenomyosis.Study designAromatase and estrone sulfatase activities were determined by anion-exchange resin column chromatography, thin-layer chromatograph…
review
1991
Leuprorelin (leuprolide, D-Leu6-(des-Gly10-NH2)-LH-RH ethylamide) acetate is a super-active agonist of luteinizing hormone-releasing hormone (LH-RH). We developed once-a-month injectable microcapsules of this agonist by our novel in-water d…
other
1991
article
1990
The development of human uterine estrogen-dependent tumors is considered to be closely related to estrogen biosynthesis. This study examined whether or not 14 alpha-hydroxy-4-androstene-3,6,17-trione (14 alpha-OHAT), a new 4-androstene-3, 1…
article
1989
Estrogen biosynthesis (aromatase activity) was investigated in human adenomyosis tissue and compared with that of the normal myometrium, endometrium, and endometrial cancer tissues. Homogenates were incubated with [1,2,6,7-3H]androstenedion…
article
1988
Leuprolide acetate is a highly potent analog of luteinizing hormone-releasing hormone. We have prepared 1-month release injectable microcapsules of leuprolide acetate using a biodegradable polymer, poly (dl-lactide-co-glycolide), to treat a…
other
1987
article
1986
To understand the mechanism of biological action of gestrinone (R2323), which has a therapeutic effect against endometriosis, the binding of gestrinone to numerous classes of intracellular steroid binding proteins was studied in the human u…
article
1985
Abstract The serum prolactin (PRL) levels of 34 cases of endometriosis, 26 cases of adeno‐m‐osis, 30 cases of functional d‐smenorrhea, and 9 patients with m‐oma uteri were measured b‐ radioimmunoassa‐. The incidence of h‐perprolactinemia (>…
article
1985
Abstract Nine patients with pelvic endometriosis were treated with gestrinone in a dose of 2.5 mg twice weekl‐ for 6 to 7 months. All patients became anovulator‐ with sporadic episodes of painless uterine bleeding lasting various periods of…
article
1984
To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, proges…
other
1983
This study was designed to clarify the effects of danazol on levels of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, progesterone (P), and 17 beta-estradiol and endometrial steroid receptors (for estrogen [E…
other
1979
Steroid receptors in endometriosis and adenomyosis were investigated to clarify their clinical significance. The receptor levels were determined by Scatchard plot analysis (4 degrees C, by dextran-coated charcoal). In the cytosols of both t…