Widjiati Widjiati

OBJECTIVE: Endometriosis is a chronic estrogen-dependent inflammatory disease that impairs fertility and quality of life. Dienogest, the current standard therapy, provides symptom relief but does not correct immune imbalance or prevent recu…

Endometriosis is a chronic gynecological disorder characterized by ectopic endometrial growth, inflammation, and mitochondrial dysfunction within the cumulus–oocyte complex (COC), leading to impaired oocyte competence. Truncated BID (tBID) …

BACKGROUND Women with endometriosis experience significantly reduced fertility, potentially linked to mitochondrial dysfunction. This study investigates the impact of endometriosis on oocyte mitochondrial morphology and cardiolipin levels, …

BACKGROUND: Endometriosis impairs female reproductive function through oxidative stress and apoptosis, reducing oocyte quality and causing infertility. Current therapies are limited by suboptimal efficacy and side effects, including ovulati…

The purpose of this study is to ascertain how nanocurcumin 0-50 nm affects malondialdehyde (MDA) levels, folliculogenesis, and the quantity of corpus luteum (CL) in a mice model of endometriosis. 24 mice were used in this scientific experim…

Endometriosis is a significant reproductive health issue with pain being the primaru symptom. The complex pain in endometriosis involves the activation of macrophages, inflammatory activators such as NF-kB, neural growth factors (NGF), cyto…

Abstract Objective Endometriosis causes a decrease in oocyte quality. However, this mechanism is not fully understood. The present study aimed to analyze the effect of endometriosis on cumulus cell adenosine triphosphate ATP level, the numb…

The objective of this study was to examine the effect of administering an ethanol extract obtained from basil leaves on the expression of vascular endothelial growth factor (VEGF) and the severity of endometriosis lesions in a mouse model. …

Background: Since endometriosis causes a decrease in oocyte quality, the success rate of in vitro fertilization cycles decreases. The purpose of the current study was to analyze the effect of endometriosis on intracellular calcium levels, C…

Endometriosis, a painful inflammatory condition, arises from the growth of endometrial tissue beyond the uterus. The anti-inflammatory properties of basil (Ocimum basilicum L.) suggest its potential as a treatment for endometriosis. This st…

Background: Women with vitamin D deficiency are at higher risk of having endometriosis. Endometriosis is a benign gynecological disease that occurs in women of reproductive age with multifactorial etiopathogenesis with high migratory and in…

HIGHLIGHTS 1. Endometriosis treatment remains controversial, whether it should be managed with hormonal modulation and/or surgical removal of the lesion.2. NF-kB becomes potential therapeutic target as it has constitutive activation in peri…

Background. In endometriosis, there is an increase in ROS levels and can cause a damage the DNA structures. Objectives. To analyze the effect of mesenchymal stem cells on the expression of BCl2 mRNA, p21 mRNA, and Survivin mRNA in mice with…

Background: As a multi-functional cytokine, interleukin-6 (IL-6) is advanced in endometriosis. Probiotics are known to be able to modulate/regulate immune responses through downregulation of the pro-inflammatory cytokine IL-6. Lactobacillus…

Background: Endometriosis is a common benign, estrogen-dependent, and chronic gynecological disease. Immune system disturbances and inflammatory abnormalities were involved in the pathogenesis of endometriosis. , Therefore, it is logical to…

Objective: Endometriosis is a gynecological syndrome that affects many women around the world. The effective management for this illness has not been determined. The aim of this study was to explore the effect of mesenchymal stem cells (MSC…

BACKGROUND AND AIM: Endometriosis affects the ovaries and causes a decrease in the oocyte quality during endometrial receptivity. During the development of ovarian follicles, paracrine communication occurs between granulosa cells and oocyte…

Background: Endometriosis is a gynaecological disorder characterised by the presence of endometrial tissue outside the uterine cavity. Apoptosis, regulated by the balance of Bcl-2/Bax, plays an important role in the endometrial improvement.…

Objective: To investigate the benefits of P. conoideus fruit extract on inflammation and angiogenesis modulation on the endometrium of endometriosis animal model. Methodology: Forty female mice (Mus musculus) were divided into two groups …

Background: The pathogenesis of endometriosis remains unclear, and involves multifactorial etiologies. The increase in oxidative stress is known to be associated with this disease. Oxidative stress increases angiogenesis and supports the pr…

Background: Increased oxidative stress causes inflammation and increases angiogenesis. It presumed to promote the proliferation of endometriosis tissue. Kebar grass (Biophytum petersianum) and other herbs such as green tea and Cucumis melo,…

Background: Peritoneal fluid (PF) from infertile women with endometriosis contains inflammatory mediators that may interfere with folliculogenesis. Objective: The aim was to evaluate the effects of curcumin on growth factors expression by e…

Objectives: To determine the effect of bone marrow mesenchy-mal stem cells (BMSCs) on BMP-15 expression and Graafian follicle count in endometriosis mice.Material and Methods: This study was a laboratory randomized clinical trial on Mus mus…

The pathological pathway of endometriosis remains unclear and involves complex etiologies. Increased oxidative stress is understood to be related to this disease. Oxidative stress produces reactive oxygen species, causes inflammation that i…