Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression

Objective: To investigate the benefits of P. conoideus fruit extract on inflammation and angiogenesis modulation on the endometrium of endometriosis animal model. Methodology: Forty female mice (Mus musculus) were divided into two groups (20 in each group). The first group was the endometriosis group. The second group was endometriosis treated with P. conoideus fruit extract. Analysis of NF-B and VEGF expression was carried out by immunohistochemistry. The analysis of endometriosis lesions was performed histologically. Results: The expression of NF-B, VEGF, and area of the endometriosis lesion was significantly reduced due to the administration of P. conoideus fruit extract. Conclusion: P.conoideus fruit extract could inhibit angiogenesis and growth of endometriosis lesions through the down regulation of NF-kB activity. This part of the plant can be an alternative herb to inhibit endometriosis progression.