C S Bambra

Anti-endometrial lymphocytotoxicity and natural killer cell activity in baboons (Papio anubis and Papio cynocephalus) with endometriosis*

To the best of our knowledge this is the first prospective study in nonhuman primates of proven fertility in the wild, which compares fertility between animals with spontaneous minimal endometriosis and those with a normal pelvis. During 7 …

The histopathology of spontaneous endometriosis was studied on 20 pelvic implants biopsied at laparoscopy in 15 healthy baboons. Endometriosis was confirmed by histopathology in 10 of these animals (66%). Typical (n = 3) and subtle (n = 13)…

BACKGROUND: Serum CA-125 during the mid-follicular phase has been reported to be a clinically useful and reproducible marker in the diagnosis of advanced endometriosis in women. This study was undertaken to document the effect of the menstr…

OBJECTIVE: To determine the incidence of spontaneous endometriosis over a 32-month period in baboons with initially normal pelves. METHODS: In this observational longitudinal study, which was performed at the Institute of Primate Research, …

OBJECTIVE: To investigate how long an ovulation stigma remains visible as determined by serial laparoscopies performed during the luteal phase in baboons. SUBJECTS AND SETTING: Sixteen female baboons with a normal pelvis (n = 6) and with e…

In women with endometriosis, changes in peripheral blood and peritoneal fluid white blood cell (WBC) populations have been reported, but it is known whether these alterations are casually related to or a consequence of endometriosis. The pu…

This study was done to test the hypothesis that the incidence and recurrence of retrograde menstruation is higher in baboons with spontaneous endometriosis than in those without. A total of 399 laparoscopies was performed on 113 female babo…

OBJECTIVES: To test the hypothesis that fertility is reduced in baboons with endometriosis. DESIGN: Prospective controlled follow-up study. SETTING: Institute of Primate Research, Nairobi Kenya. SUBJECTS: Seventy-one baboons, including 3…

BACKGROUND: It is not known whether stress affects the prevalence of endometriosis in women. Baboons with spontaneous endometriosis may be interesting models to study the human disease. For baboons, living in captivity is a period of chroni…

This study was performed to test the hypothesis that anti-endometrial, lymphocyte-mediated cytotoxicity and natural killer (NK) activity are reduced in baboons with endometriosis when compared to animals with a normal pelvis. Lymphocyte-med…

OBJECTIVE: To test the hypothesis that immunosuppression increases the development and progression of endometriosis in baboons. DESIGN: Experimental controlled study. SETTING: Institute of Primate Research, Nairobi, Kenya. PARTICIPANTS: …

To document the spontaneous evolution of endometriosis, a repeat laparoscopy was performed in 11 baboons after 10 and/or 12 months. The mean number of endometriotic lesions had increased significantly after 10 months (P less than 0.02) beca…

The prevalence of spontaneous endometriosis was investigated by laparoscopy in 52 baboons (Papio anubis and Papio cynocephalus) of proven fertility. Clinical endometriosis was diagnosed in 9 (17%) and 4 (8%) baboons with or without a previo…