Xiaoling Fang

Objective: The aim was to assess the efficacy of post-operative adjuvant treatment with goserelin acetate for reducing the recurrence of pelvic symptoms and total recurrence rates in Chinese patients with moderate to severe endometriosis.

OBJECTIVE: To investigate the therapeutic mechanism of letrozole, the third-generation aromatase inhibitor, on endometriotic lesions in a rat model and its effect on the apoptosis of ectopic endometrial cells. METHODS: Endometriosis was ind…

【Objective】 To study the role and significant of serum erythropoietin(EPO) and epithelial neutrophil-activating peptide-78(ENA-78) in patient with endometriosis.【Methods】 Serum concentrations of EPO and ENA-78 were measured by means of enzy…

OBJECTIVE: To examine the expression of DNMT1, DNMT3a, and DNMT3b in the eutopic and ectopic endometrium in women with endometriosis. METHODS: RT-PCR and real-time RT-PCR were used to examine the expression of DNMT1, DNMT3a, and DNMT3b in t…

Endometriosis (EMs) is an estrogen-dependent disease, and aromatase is the key enzyme in the biosynthesis of estrogen. In reccent years, studies showed that aromatase inhibitors (AIs) have been used effectively to treat patients with endome…

【Objective】 To investigate the effect of GnRHa on the cell proliferation and VEGF's secreting of ectopic and eutopic endometrial stromal cells from patients with endometriosis(EMs) in vitro.【Methods】 The ectopic and eutopic endometrial stro…

【Objective】 To investigate the expression of ezrin in endometriosis for exploring the role of ezrin in the pathogenesis of endometriosis.【Methods】 Immunohistochemistry and RT-PCR were used to detect the expression of ezrin in the eutopic an…

Objective To investigate the.expression and significance of peritoneal fluid (PF) erythropoietin (EPO) and neutrophils activation peptide-78 (ENA-78)in patients with endometriosis.Methods The levels of EPO and ENA-78 in peritoneal fluid (PF…

Objective To investigate the expression CD44v6 and Smad7 in endometriosis and the role of CD44v6 and Smad7 in the pathogenesis of endometriosis.Methods The expressions of CD44v6 and Smad7 were detected with immunohistochemiscal technic in 3…

OBJECTIVE: To explore the influence of carbon dioxide pneumoperitoneum-laparoscopic surgery on tumor cell seeding and metastases in endometrial cancer. METHODS: Twenty patients with endometrial cancer who underwent laparoscopic surgery and …

【Objective】To explore the pathogenesis of infertility for directing the methods of treatment and prevention.【Methods】Twenty-two-hundred cases of infertility were selected in order to discover the types and pathogenesis of the infertility.【R…

【Objective】To evaluate whether these alteration could provide causative and progressive information.【Methods】The concentration of HGF and VEGF was studied by enzyme-linked immunosorbent assay(ELISA) methods in 25 cases of endometriosis and …

To explore the clinical value of laparoscopy combined with post-operative medication therapy for treatment of endometriosis. Retrospectively analysis of situations about 96 endometriosis patients who were under laparoscopy combined with pos…

OBJECTIVE: To determine the effect of progesterone on the secretion of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in ectopic endometrial stromal cells. METHODS: Ectopic endometrial stromal cells were obtained …

OBJECTIVE: To investigate the expression of cyclooxygense-2 (COX-2) in eutopic and ectopic endometrium in ovarian endometriosis. METHODS: Thirty patients with ovrian endometriosis, 10 with ovarian chocolate cysts and 27 normal controls were…

OBJECTIVE: To study the pathophysiological effect of the expression of the apoptosis-regulating protein Bcl-2 and Bax in endometrosis. METHOD: Samples were obtained from 16 patients with adenomyosis, 12 ovarian endometriosis, and 17 normal …

OBJECTIVE: To investigate the significance of vascular endothelial growth factor (VEGF) on the etiology of endometriosis. METHODS: The level of VEGF in the peritoneal fluid from women with endometriosis (n = 19) and non-endometriosis (n = 2…

AIM: To explore the role of microenvironment of peritoneal fluid in pathogenesis of endometriosis, the source and its regulation in peritoneal fluid. METHODS: Peritoneal Mphis from 14 patients with endometriosis (endometriosis group)and 10 …

OBJECTIVE: To study the possibility of a correlation between occurrence of endometriosis (EM) and polymorphism of human leukocyte antigen (HLA) DRB1 allele. METHODS: Polymorphism of HLA-DRB1 allele were detected by polymerase chain reaction…