L. Wildt

Endometriosis is a common problem affecting 5-10% of women of childbearing age. It is a condition with unknown pathology, leaving us with several theories. However, about half of women with endometriosis complain of difficulty conceiving. T…

There are several limitations to assess immunohistochemical staining in the cells manually such as wide differences in the qualifications of researchers working with histological samples, infeasible to count every single cell, time consumin…

The selected endometriosis tissue required the presence of glandular epithelial cells and stromal cells. ROI were developed by selecting â customâ mode applied to separate lumen, epithelial gland tissue and stromal tissue. The lumen ROI was…

Setting parameter for nuclei size. The nucleus size was determined as depicted in Fig. 4a. It was based on blue color detection (hematoxylin staining). Brown color expressed by cell was restricted from interior radius −4,81 μm to exterior r…

Manual counting of nerve fibers. Region of interests were selected randomly and marked with a border to obtain an area of 1Â mm2 each. A single nerve fiber was marked manually by using a tool available in HistoquestÂŽ software. (JPG 565Â kb…

© The Author(s) 2009. This article is published with open access at Springerlink.com Introduction This study presents a unifying concept of the pathophysiology of endometriosis and adenomyosis. In par-ticular, a physiological model is propo…

Purpose In a series of publications, we had developed the concept that uterine adenomyosis and pelvic endometriosis as well as endometriotic lesions at distant sites of the body share a common pathophysiology with endometriosis constituting…

BACKGROUND: The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related k…

PURPOSE: In a series of publications, we had developed the concept that uterine adenomyosis and pelvic endometriosis as well as endometriotic lesions at distant sites of the body share a common pathophysiology with endometriosis constitutin…

STUDY QUESTION: What is the safe and pharmacodynamically active dose range for PDC31 (prostaglandin F2α receptor inhibitor) in patients with primary dysmenorrhea (PD)? SUMMARY ANSWER: The 1 mg/kg/h dose of PDC31 appears to be safe and poten…

Pelvic endometriosis, deeply infiltrating endometriosis and uterine adenomyosis share a common pathophysiology and may be integrated into the physiological mechanism and new nosological concept of 'tissue injury and repair' (TIAR) and may, …

Einleitung: Unter der selten auftretenden extragenitalen Endometriose nimmt die pulmonale Form eine Sonderstellung ein. Bedingt durch die zyklusabhängigen Blutungen können Spontanpneumothoraces auftreten, die oft nicht in Zusammenhang mit E…

Pelvic endometriosis, deeply infiltrating endometriosis, and uterine adenomyosis share a common pathophysiology and may be integrated into the physiological mechanism and new nosological concept of “tissue injury and repair” and may, in thi…

The major authors of the last century described endometriosis as ectopic endometrial lesions occurring both in the uterus and in the peritoneal cavity, and the lesions were considered as variants of the same disease process. In the 1920s a …

Context Previous studies have implicated a deficiency in the inflammatory response in women who develop endometriosis. The specific immunological deficits have not been completely elucidated. Objective Our objective was to identify differen…

Context: Previous studies have implicated a deficiency in the inflammatory response in women who develop endometriosis. The specific immunological deficits have not been completely elucidated. Objective: Our objective was to identify differ…

CONTEXT: Previous studies have implicated a deficiency in the inflammatory response in women who develop endometriosis. The specific immunological deficits have not been completely elucidated. OBJECTIVE: Our objective was to identify differ…

The objective of this case-control study of 242 reproductive-age women was to determine the concentration of afamin in the serum and peritoneal fluid of women with and without endometriosis and to test afamin as a diagnostic marker of endom…

Fragestellung: Die Endometriose ist eine häufige Erkrankung während der reproduktiven Lebensphase der Frau, die mit chronischen Schmerzen und Subfertilität einhergeht. Ihre Diagnose beruht auf dem laparoskopischen und histologischen Nachwei…