Efficacy and safety of a novel oral contraceptive based on oestradiol (oestradiol valerate/dienogest): A Phase III trial

Santiago Palacios; L. Wildt; Susanne Parke; A. Machlitt; Thomas Römer; Johannes Bitzer

doi:10.1016/j.ejogrb.2009.11.001

Efficacy and safety of a novel oral contraceptive based on oestradiol (oestradiol valerate/dienogest): A Phase III trial

Santiago Palacios, L. Wildt, Susanne Parke, A. Machlitt, Thomas Römer, Johannes Bitzer

In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 2009 · vol. 149(1) , pp. 57–62 · doi:10.1016/j.ejogrb.2009.11.001 · PMID:19969409 · W2036683659

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This Phase III trial evaluated the efficacy and safety of a novel oral contraceptive containing oestradiol valerate and dienogest.

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References (27)

Approaches to the replacement of ethinylestradiol by natural 17β-estradiol in combined oral contraceptives via openalex
Bleeding pattern and cycle control with an estradiol-based oral contraceptive: a seven-cycle, randomized comparative trial of estradiol valerate/dienogest and ethinyl estradiol/levonorgestrel via openalex
Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile via openalex
Effect of four oral contraceptives on hemostatic parameters via openalex
Efficacy of a combined oral contraceptive containing 0.030 mg ethinylestradiol/2 mg dienogest for the treatment of papulopustular acne in comparison with placebo and 0.035 mg ethinylestradiol/2 mg cyproterone acetate via openalex
New progestagens for contraceptive use via openalex
Ovulation inhibition with four variations of a four-phasic estradiol valerate/dienogest combined oral contraceptive: results of two prospective, randomized, open-label studies via openalex
Pharmacokinetics of an oral contraceptive containing oestradiol valerate and dienogest via openalex
The pharmacological profile of dienogest via openalex
doi:10.1016/j.contraception.2004.05.013 via openalex
doi:10.1111/j.1471-0528.1979.tb11276.x via openalex
doi:10.1016/s0015-0282(16)56210-4 via openalex
doi:10.1016/0002-9378(82)90218-6 via openalex
doi:10.1016/s0010-7824(96)00201-6 via openalex
doi:10.3109/00016348209155333 via openalex
doi:10.1007/bf01849449 via openalex
doi:10.1016/s0140-6736(00)04615-8 via openalex
doi:10.1016/0378-5122(94)00856-3 via openalex
doi:10.1080/13625180008500378 via openalex
doi:10.1016/s0140-6736(79)91525-3 via openalex
doi:10.1055/s-0038-1646528 via openalex
doi:10.3109/00016348709015732 via openalex
doi:10.1016/0010-7824(80)90010-4 via openalex
doi:10.1016/j.contraception.2006.07.004 via openalex
doi:10.1016/s0010-7824(00)00133-5 via openalex
W2423459841 via openalex
W2749570783 via openalex

Cited by (40)

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License: CC0 · commercial use OK

[1] Approaches to the replacement of ethinylestradiol by natural 17β-estradiol in combined oral contraceptives via openalex

[2] Bleeding pattern and cycle control with an estradiol-based oral contraceptive: a seven-cycle, randomized comparative trial of estradiol valerate/dienogest and ethinyl estradiol/levonorgestrel via openalex

[3] Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile via openalex

[4] Effect of four oral contraceptives on hemostatic parameters via openalex

[5] Efficacy of a combined oral contraceptive containing 0.030 mg ethinylestradiol/2 mg dienogest for the treatment of papulopustular acne in comparison with placebo and 0.035 mg ethinylestradiol/2 mg cyproterone acetate via openalex

[6] New progestagens for contraceptive use via openalex

[7] Ovulation inhibition with four variations of a four-phasic estradiol valerate/dienogest combined oral contraceptive: results of two prospective, randomized, open-label studies via openalex

[8] Pharmacokinetics of an oral contraceptive containing oestradiol valerate and dienogest via openalex

[9] The pharmacological profile of dienogest via openalex

[10] doi:10.1016/j.contraception.2004.05.013 via openalex

[11] doi:10.1111/j.1471-0528.1979.tb11276.x via openalex

[12] doi:10.1016/s0015-0282(16)56210-4 via openalex

[13] doi:10.1016/0002-9378(82)90218-6 via openalex

[14] doi:10.1016/s0010-7824(96)00201-6 via openalex

[15] doi:10.3109/00016348209155333 via openalex

[16] doi:10.1007/bf01849449 via openalex

[17] doi:10.1016/s0140-6736(00)04615-8 via openalex

[18] doi:10.1016/0378-5122(94)00856-3 via openalex

[19] doi:10.1080/13625180008500378 via openalex

[20] doi:10.1016/s0140-6736(79)91525-3 via openalex

[21] doi:10.1055/s-0038-1646528 via openalex

[22] doi:10.3109/00016348709015732 via openalex

[23] doi:10.1016/0010-7824(80)90010-4 via openalex

[24] doi:10.1016/j.contraception.2006.07.004 via openalex

[25] doi:10.1016/s0010-7824(00)00133-5 via openalex

[26] W2423459841 via openalex

[27] W2749570783 via openalex